M4_3-student - Unit 3 How do we determine structure? Module...

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Chemistry XXI Unit 3 How do we determine structure? Module 4: Analyzing Interactions Central goal: To predict the nature and strength of the interactions between different parts of a molecule, or between different molecules, based on the analysis of charge distribution on each particle.
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Chemistry XXI The Challenge Many molecules have properties that depend on how their different geometric centers orient with respect to each other in space. A small change in this conformation may alter the properties or vital function that the molecule has. How can we explain and predict the conformation that molecules as complex as proteins and DNA may have? Modeling How do I explain it? The specific conformations that molecules adopt depend on intra and intermolecular interactions.
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Chemistry XXI Dynamic Structures Molecules are dynamic structures that are in constant movement even in solid systems. For molecules with more than one geometric center, this movement may allow them to take different conformations . The most stable conformations are determined by the nature of the interactions within the molecule and between the molecule and its surroundings.
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Chemistry XXI Conformational Analysis Let’s consider the molecule Staggered (stable) More likely Eclipsed (unstable) Less likely, but possible How do you explain the variations in E ? Which
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Steric Effects When atoms in a molecule get too close together as parts of the molecule vibrate or rotate, electric repulsions between electrons may hinder some conformations and favor others ( Steric effects ). Steric effects
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This note was uploaded on 04/09/2009 for the course CHEM 151 taught by Professor Staff during the Fall '08 term at University of Arizona- Tucson.

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M4_3-student - Unit 3 How do we determine structure? Module...

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