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Unformatted text preview: o Heterozygote advantage (e.g. sickle-cell anemia)-Epistasis o Alleles at one locus alter expression of alleles at another locus (e.g. albinism)-Polygenic inheritance o Additive effects of alleles at multiple loci on the same phenotype Other genetic concepts-Pleiotropy o The effect of e gene on multiple features of an organism (e.g. mutation affecting eye color and deafness in cats)-Penetrance o Probability that a phenotype will be expressed for a particular genotype (e.g. Type I diabetes in monozygotic twins)-Expressivity o The degree to which the phenotype is expressed (e.g. male tail tip lengths in lin-41 (gf) mutants of C. elegans ) The multifactorial phenotype-Phenotype also results from interaction between genotype and environment (and epigenetics – not everything you inherit is from DNA)-Ex. Soil acidity yields diff color hydrangeas, butterflies born diff colors in diff seasons....
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- Spring '08
- Genetics, multifactorial phenotype