BIO 320 Lecture5.2009.ho

BIO 320 Lecture5.2009.ho - Membrane Traffic: The Secretory...

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1 Membrane Traffic: The Secretory Pathway, The RER, Signal Peptides, Membrane Proteins Eukaryotic Cells: Membrane-Bound Compartments Membrane Traffic ** Secretory Traffic Endocytic Traffic Electron micrograph of membranes in secretory pathway RER “free” ribosomes Golgi stacks Cooper 9.22 Fig 12-40 Fig 12-40
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2 Free vs. bound ribosomes Cooper 9.3 How do “bound” ribosomes bind the RER? Signal Sequences Alberts, 2002 Signal sequence of Growth Hormone: Targeting Signal to the RER Cooper 9.6 Most signal sequences: an amino-terminal stretch of nonpolar (hydrophobic) residues accompanied by basic residues (I.e. arg.) ER ER S ignal R ecognition P article Composed of 6 distinct polypeptides + Small RNA molecule (7SL) SRP Binds Signal Peptide ER Signal Recognition Particle Lodish 17-17 A secreted protein --nascent peptide to the RER Alberts, fig 12-38
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3 A secreted protein --nascent peptide to the RER Alberts 12-40 1. Signal peptide emerges - binds SRP Translation STOPS A secreted protein --nascent peptide to the
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BIO 320 Lecture5.2009.ho - Membrane Traffic: The Secretory...

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