BIO 320 lec7.2009.notes - Lecture 7 Traffic from the ER to...

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1 Lecture 7 Traffic from the ER to the Golgi What happens to proteins in these compartments? How do proteins travel between compartments? Vesicle Fusion: How does a vesicle fuse with its appropriate target membrane? SNARE Proteins Provide Specificity to Vesicle Targeting The SNARE Complex: t-snare + v-snare 13-16 T-Snare/V-snare Complexes Are so Stable That Energy is Required to Pry Them Apart 13-18 Botox: Botulinum toxin A, a protease for t-snare SNAP-25 at the neuromuscular junction.
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2 How SNARE’s participate in Membrane fustion Lipids of the two bilayers flow Together ----------> Alberts 13-17 Rab Proteins and Their “Effectors” Also Provide Specificity to Transport Vesicle Targeting 13-14 Different Rabs on different Targets What happens to polypeptides that are transported into the RER? N-linked glycosylation Alberts 12-50 Glycosylation in the ER Carbohydrate transferred to Asparagines (N) from dolichol Alberts 12-51
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3 Folding and Quality control in the ER: out through the translocon, ubiquitination, and
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BIO 320 lec7.2009.notes - Lecture 7 Traffic from the ER to...

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