BIO 320 lec8.2009.notes

BIO 320 lec8.2009.notes - Lecture 7 Resident ER Proteins...

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1 Lecture 7 Traffic in the Golgi Decisions at the Trans-Golgi Network Lysosomes Signals on Proteins determine Route Resident ER Proteins “escape” from the ER Karp 8.25 How do ER resident proteins remain in ER? 1. What ARE ER resident proteins? 2. Hypothesis: Signal sequence on resident ER proteins acts to traffic proteins back to the ER 3. How would you identify this signal sequence? C-terminal sequences of ER Resident proteins Sequence from vertebrates, insects, plants, fungi, protozoa KDEL is most commonly found, with variation At c-terminus……. .. i.e.: Bip, an ER chaperone, and PDI have KDEL at c-terminus Common sequences is consistent with hypothesis Signal sequence on resident ER proteins acts to traffic proteins back to the ER Is this signal sequence necessary for sorting? Is this signal sequence sufficient for sorting? Common sequences are suggestive- Is sequence necessary for proper sorting of ER resident protein to ER ? BiP as an example: What is Bip?
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This note was uploaded on 04/12/2009 for the course BIO 50160 taught by Professor O' halloran during the Spring '09 term at University of Texas.

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BIO 320 lec8.2009.notes - Lecture 7 Resident ER Proteins...

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