BIO 320 Lec9.2009.handout

BIO 320 Lec9.2009.handout - Lecture 9 Membrane Traffic...

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1 Lecture 9 Membrane Traffic: Lysosomes Exocytosis Endocytosis Lysosomes Organelles that contain lysosomal enzymes: Enzymes of destruction: phosphatases, nucleases,proteases, oligosaccharidases, lipid hydrolyzing enzymes Karp 8.32 How is a signal used to traffic lysosomal enzymes from TGN to Lysosomes? Signal: Protein is tagged with Man-6 P Receptor in TGN: Man-6-P Receptor Figure 13-43 Molecular Biology of the Cell (© Garland Science 2008) M6P Specifically Marks Acid Hydrolases Within The TGN For Delivery To Late Endosomes Man-6-Phosphate Receptor Sorts Lysosomal Enzymes to Lysosomes 13-44 Clathrin Coated Vesicles Carry Man-6-Phosphate Receptor to pre-lysosomal Compartment
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2 AP-1 in Clathrin CV’s at the TGN; AP-2 in Clathrin CV’s at the Plasma Membrane TGN PM Three Distinct Vesicle Coats COP = coatomer protein Four! Proteins carry SIGNALS for sorting to appropriate compartment EXCEPTION: Constitutive secretion. WITHOUT A SIGNAL, PROTEIN WILL FOLLOW SECRETORY PATH: ER ---> Golgi ---> Pl. Membrane
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