BIO 320 Lecture10slides_2009

BIO 320 Lecture10slides_2009 - BIO320 - Lecture 10...

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1 BIO320 - Lecture 10 02/19/2009 NUCLEAR TRANSPORT Optional Reading on Blackboard Science (2006) 314: 766-767 The Nucleus may have originated by invagination of the Plasma Membrane in early Eukaryotic Cells This model explains the relationship between the Nucleus and the Secretory membranes Alberts 12-4 Alberts 12-8 The structure of the Nuclear Membrane Alberts 12-19 The Nuclear Lamina gives support to the Nuclear Membrane Made from Intermediate Filaments Free diffusion Ions, ATP, small proteins <50 kDa mRNAs tRNAs Shuttling proteins Nuclear proteins Ribosomal proteins Ribosomal subunits Many proteins and RNAs are transported in/out of the nucleus The NPC is a selective gate for traffic into the nucleus < ~50 kDa > 50 kDa Alberts 12-10
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2 Structure of the nuclear pore complex (NPC) > 30 times the size of a ribosome! Alberts 12-9 A New Model of the Channel within the Nuclear Pore The Nuclear Pore contains many proteins called nucleoporins that fill the channel forming a gel that excludes large proteins. Science (2006) 314: 766-767
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BIO 320 Lecture10slides_2009 - BIO320 - Lecture 10...

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