BIO 320 Lecture11_2009

BIO 320 Lecture11_2009 - A.DeLozanne Lecture11...

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BIO 320 - CELL BIOLOGY – Spring 2009 A. De Lozanne Lecture 11. Transport of Proteins into Mitochondria Reading: Alberts, 5th Ed. Pages 713-719 the following sections: The Transport of Proteins into Mitochondria  Translocation into the mitochondrial matrix depends on… Mitochondrial precursor proteins are imported as unfolded… ATP hydrolysis and a Membrane Potential drive… Transport into the Inner Mitochondrial Membrane… PLUS: The mitochondrion contains an outer membrane, an …pp 816-817 The citric acid cycle generates high-energy electrons As electrons move along the respiratory chain, …pp 820 The proton gradient drives ATP synthesis, pp 821 The proton gradient drives coupled transport. .., pp 822 Figures 14-14 and 14-15 OPTIONAL READING: review article on mitochondria evolution the nucleus Molec. Phylogenet. Evol. 29:380-395  (posted on Blackboard) Outline I. Mitochondria: Organization and Function. A.  Evidence that mitochondria originated by endosymbiosis: 1. Mitochondria have a size similar to that of bacteria . 2. Mitochondria have their own genome that encodes their own ribosomal subunits, tRNAs,  and some of the mitochondrial proteins. 3. The sequence of the mitochondrial genes is most similar to purple bacteria than to related  genes of the host cell. 4.
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BIO 320 Lecture11_2009 - A.DeLozanne Lecture11...

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