BIO 320 Lecture12-13_2009slides

BIO 320 Lecture12-13_2009slides - BIO320 - 2009 Lectures 12...

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1 Introduction to Cytoskeleton Microtubule Cytoskeleton Microtubule-based Motility BIO320 - 2009 The Endoplasmic Reticulum is Closely Associated with the Microtubule Cytoskeleton ER MT The Distribution of the Endoplasmic Reticulum is Produced by Interactions with Microtubules Membrane Traffic occurs along the “Tracks” of the Cytoskeleton filaments ER to Golgi traffic visualized with GFP The cytoskeleton A system of filaments Karp 9.10 The Cytoskeleton is Essential to Eukaryotic Cells • Chromosome Separation • Cell Division • Cell Shape, Motility, and Mechanical Integrity • Membrane Vesicle and Organelle Movement • Muscle Contraction • Axon Formation • Etc. Mitosis Muscle Neurons The Cytoskeleton Consists of Three Major Cytoskeletal Systems • Microtubules • Intermediate Filaments • Microfilaments Thickness 24 nm 10 nm 8 nm Subunit -Tubulin -Keratin, etc. -Actin Some bacteria have similar proteins
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2 Building Blocks GTP ATP The Formation of The Three Filament Systems Have Two Fundamental Properties in Common • Polymers of Smaller Protein Subunits Allows Dynamic Remodeling • Individual Filaments Consist of “Protofilament” Bundles Provides Mechanical Strength Dynamic Remodeling Alberts 16-7 Single Protofilaments are not very Strong Alberts 16-8 Protofilament Bundles Are Stronger Alberts 16-8 The Assembly of Microtubules and Microfilaments have Several Properties in Common Filaments have polarity Concentration dependent Use a nucleotide to control assembly/disassembly Require a nucleus
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This note was uploaded on 04/12/2009 for the course BIO 50160 taught by Professor O' halloran during the Spring '09 term at University of Texas.

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BIO 320 Lecture12-13_2009slides - BIO320 - 2009 Lectures 12...

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