BIO 320 Lec17.notes.2009

BIO 320 Lec17.notes.2009 - Cells are organized into tissues...

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1 Lecture 17 Cell-Cell Interactions and Connections Karp 7.1 collagen fibers Cells are organized into tissues Epithelium: cells that cover and line: Intestine Skin lung Skin . Selective Interactions between Cells: critical during development Cells can recognize the surfaces of other cells -ignore some -interact with others HOW? Karp 7.11 Experimental demonstration: Cell-cell recognition Karp 7.19 Cells tend to adhere preferentially Cell-Cell adhesion Karp 7.19 See Alberts 19-10 Cell Surface Receptors: 1. Cadherins 2. Selectins 3. Immunoglobulin Superfamily 4. Integrins (certain members) Cadherins Cell-adhesion “zippers” 19.9
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2 Figure 19-9a Molecular Biology of the Cell (© Garland Science 2008) Cadherins Calcium important for keeping cadherin in correct conformation 19.9 Cadherins mediate cell sorting during development Figure 19-13 Molecular Biology of the Cell (© Garland Science 2008) Cadherins link to actin cytoskeleton via catenins.
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