BIO 320 Lec18.2009.notes

BIO 320 Lec18.2009.notes - Lecture 18 Extracellular Matrix:...

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1 Lecture 18 Extracellular Matrix: Interactions between Cells and Their Environment Figure 19-3 Molecular Biology of the Cel (© Garland Science 2008) Gap Junction • Mediate intercellular communication • Cells come close, but do not contact. • “pipelines” made by connexon proteins that span the membrane Karp 7.32 Gap junction: connexon Karp 7.32, see alberts19-34 Central opening: 1.5 nm in diameter Non-selective: Allows passage of <1000 Dalton particles Closure regulated: phosphorylation Two General Types of Cell Junctions in Epithelial Cells cell-cell junctions cell-matrix junctions function seal anchor anchor communicate anchor Figure 19-18 Molecular Biology of the Cel (© Garland Science 2008)
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2 Another Cell-substrate junction: the hemidesmosome Karp, 7.18 -at basal surfaces of epithelial cells “spot welds” between Epithelial cells and the underlying extracellular space in out The hemidesmosome -Integrins connect ECM with intermediate filaments (I.e. keratin) An example: connect the epidermis with the dermis Contain: Intermediate filaments Anchor into plaque w/ plectin + dystonin AND integrin
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BIO 320 Lec18.2009.notes - Lecture 18 Extracellular Matrix:...

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