BIO 320 Lecture19_2009slides

BIO 320 Lecture19_2009slides - BIO320 - Lecture 19 Cell...

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1 BIO320 - Lecture 19 http://www.wehi.edu.au/education/wehi-tv/movies.html Alberts CD Karp 14-1 Important Questions about DNA Replication 1. How can all chromosomes replicate at the same time of the cell cycle? 2. How can very large chromosomes replicate completely in a narrow window of time? 3. How do errors get corrected? 4. How does the cell have enough time to correct errors in DNA replication? 5. Why do chromosomes replicate only once during each cell cycle? DNA Replication starts at Replication Origins and proceeds bidirectionally Bacteria chromosome with one origin Eukaryotes have multiple origins of replication Karp 13-19 See Alberts 5-29 Old Alberts 17-22 Initiation of DNA Replication (not a checkpoint) • Origin Recognition Complex proteins are always bound to origin of replication DNA • Cdc6 is made transiently in G1 • Binding of cdc6 and MCMs to ORC makes pre-RC (ready to fire) • MCMs = DNA helicase • Activation of S-Cdk triggers
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BIO 320 Lecture19_2009slides - BIO320 - Lecture 19 Cell...

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