BIO 365R Lecture 8 - Ion channels and disease Hyperkalemic...

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Ion channels and disease Hyperkalemic periodic paralysis (HYPP)--muscle. Long QT syndrome (LQT)--cardiac. Lambert-Eaton syndrome (LES)--motor neuron.
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Ion channels and disease Hyperkalemic periodic paralysis (HYPP)--muscle. Hyperkalemia: blood K + levels; following exercise or eating K + -rich food. Periodic paralysis: a paralysis that occurs periodically. Symptoms: muscle stiffness (myotonia), to paralysis of shoulder, hips, or limbs. Episodes last a few hours. Affects humans and horses (descendents of “Impressive”).
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HYPP segregates as a dominant trait. http://www.tufts.edu/vet/vet_common/images/sports/hypp/figure1.jpg
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The muscle Na + channels of HYPP patients do not fully inactivate. Normal muscle; HYPP muscle in normal K + HYPP muscle in K + Cannon & Corey, 1993
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The muscle action potential is longer The response to increasingly longer duration current pulses Normal HYPP
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Depolarization of HYPP muscle causes plateau potentials and spontaneous action potentials. Current pulse mimics depolarization due to synaptic activation.
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potentials and spontaneous action potentials. Normal muscle:
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This note was uploaded on 04/12/2009 for the course BIO 51340 taught by Professor Zakon during the Spring '09 term at University of Texas at Austin.

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BIO 365R Lecture 8 - Ion channels and disease Hyperkalemic...

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