BIO 365R Lecture16_smooth_muscle

BIO 365R Lecture16_smooth_muscle - Smooth muscle...

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Smooth muscle • “involuntary” muscle under autonomic control. • In lining of arteries and veins (changes in (peristalsis), iris of the eye (accommodation), lining of uterus (contractions during birth), airways to the lungs (contracted during asthma), at the base of hair follicles (to raise hair).
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actin
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Ca entry in cell through voltage sensitive Ca channels calmodulin Ca activated calmodulin myosin light chain kinase (inactive) kinase-Ca - calmodulin (active kinase) myosin (inactive) ATP ADP ++ ++ ++ ++ P Myosin - (active) myosin light chain phosphatase P
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Dyhydropyridine (DHP) receptors • The DHP receptors in skeletal muscle are modified Ca 2+ channels that mechanically interact with the ryanodine receptors of the SR to let Ca 2+ into the cell from the SR . • In smooth muscle and cardiac cells, the DHP receptor (i.e.--calcium channel) functions like a real Ca 2+ channel and lets Ca 2+ into the cell from the extracellular fluid .
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BIO 365R Lecture16_smooth_muscle - Smooth muscle...

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