BIO311C_F08_Chapter_17_part_3

BIO311C_F08_Chapter_17_part_3 - Mutations 344-346, 316-318...

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Unformatted text preview: Mutations 344-346, 316-318 Fig. 17-22 Wild-type hemoglobin DNA mRNA Mutant hemoglobin DNA mRNA 3 3 3 3 3 3 5 5 5 5 5 5 C C T T T T G G A A A A A A A G G U Normal hemoglobin Sickle-cell hemoglobin Glu Val Lysis of RBC Low RBC counts Clog BV Cause of mutations Spontaneous mutations Can occur during DNA replication, repair etc Mutagens Are physical or chemical agents that can cause mutations Point mutations Are changes in just one base pair of a gene Can affect protein structure/function Types of Point Mutations Point mutations within a gene can be divided into two general categories Base-pair substitutions Nucleotide pairs substituted Base-pair insertions or deletions Add or delete nucleotide pairs Base pair substitutions Is the replacement of one nucleotide and its partner with another pair of nucleotides Silent Missense Nonsense 1) Silent mutations have no effect on the amino acid produced by a codon because of redundancy in the genetic code Fig. 17-23aFig....
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BIO311C_F08_Chapter_17_part_3 - Mutations 344-346, 316-318...

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