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Problem Set 8 questions

Problem Set 8 questions - CELL BIOLOGY PROBLEM SET 8 1...

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  CELL BIOLOGY PROBLEM SET 8  1. There are many proteins that are important for the forward and return pathways from  the RER to Golgi.  Explain the roles of the different COPS and SNARES in this  transport. o Golgi <> RER RER don’t have a path Hit Golgi No fusion Cops and Snares Rough ER and golgi Soluble cargo protein, gets into vesicle, Cop2 When Cop proteins come off, called snares Snare pair are like ligand and receptor B snare o Part of Vesicle T snare  o Part of vesicle, golgi Return o Same thing in reverse 2. How does a cell retain RER specific proteins in the RER? 3. What is the importance of N-acetylglucosamine phosphotransferase with respect to the  proper transport of hydrolytic enzymes in the golgi, TGN, and lysosomes? 4. Describe the definitive experiment that was crucial for the original discovery of the  TGN. MDCK Cells Cells grown on microporous membrane Once technology was developed by Milicorp, different possibilities o Carl Matlin and Keith Mastroff Viral infection of MDCK cells 2 different proteins looked at aplical surface
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see proteins from influenza virus HA glycoprotein on  aplical Glycoprotien is on basal surface Question: How did the cell know how to sort the proteins? Knew all proteins went into Golgi together Serendipity o New Organelle, Transgolgi Network o How was it seen?
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Problem Set 8 questions - CELL BIOLOGY PROBLEM SET 8 1...

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