march 12 - Anatasia Gangadin Today Finish second messengers...

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Anatasia Gangadin Page 1 10/6/2009 Today: Finish second messengers Start Protein synthesis / trafficking cAMP Produced by Adenylyl cyclase Controlled by GS or GI protein o S= Stinulatory o I= Inhibatory Question: What part of the receptor is unique that it lets you bind? o Chimeric Protein Not the protein, but the receptor 2 options o PDE 5’ amp, inactive o Cyclic AMP dependant protein kinase o How can you study this system? Regulatory Units Bind cyclic AMP o cAMP analogs o 8- azido cAMP 32 Photoaffinity Analogs o Where does the catalytic unit work in the cell Multiple places Cytoplasm o Glycogen synthesis/ breakdown Cell membrane Nucleus Protein Kinase C (IP3 DAG) GPCR o There is a g protein, hence, start with GPCR Bind to the affector Phosolipase C Not adenocyclase Has a target substrate, a specific phospholipids o IP3 binds to ER o Increase of Calcium from Endoplasmic Reticulum o DAG binds to PKC o Cell Membrane channels have to open Calcium calmodulin Calcium binding proteins
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Anatasia Gangadin Page 2 10/6/2009 o EG Calmodulin NO
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This note was uploaded on 04/13/2009 for the course BIOL 311 taught by Professor Vanbuskirk during the Spring '08 term at Binghamton.

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march 12 - Anatasia Gangadin Today Finish second messengers...

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