march 5 notes

march 5 notes - Anatasia Gangadin Cell Molecular Biology...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
Anatasia Gangadin Page 1 10/6/2009 Cell Molecular Biology Exam and Average is posted Avg is 79.5%, B- Today: Finish cell membranes Start receptors Start Signal Transduction Cell Junctions Adherers Junction o Presence Epithelial cells endothelial cells o Distinguished from Desosomes by cadherins Important because they are calcium dependant Important because To separate cells, need to work on the cadherin Transmembrane protein Indirectly tied to F actin Cytoskeletal protein Adhesion and strength Desmosomes o Presence Epithelial and endothelial o Spot weld o E Cadherins are important as other cadherins o Examples Human Skin In engineered skin, there are lots of desmosomes but the key thing is if they are connected correctly Intermediate filaments o In skin, keratin filaments Basal lamina (like basement membrane) Disease states Pemphigus Vulgaris o Autoimmune disease against desmoglein 3 Pempligus Foliaceus o Autoimmune disease against desmoglein 1 Pemphagoid o Autoimmune disease against hemidesmosomes o Skin peels off in sheets Gap Junctions o Electrical junctions o Many Celltypes Eye source Epithelial
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Anatasia Gangadin Page 2 10/6/2009 Cell Molecular Biology Endothelial o What are they? 2 cells are connected by very small pores Freeze fracture and entire gap junction is visible The pore, Connexon, look like petals of flower, and will extend between cells Proteins Pass ions and small molecules Tight Junctions o Designed to maintain a fluid barrier o Used to be called Zonula Occulens Separated fluid compartments o Presence Kidney cells Bladder Cells
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 6

march 5 notes - Anatasia Gangadin Cell Molecular Biology...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online