macrh 10 - Anatasia Gangadin Cell Molecular Biology Page 1...

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Anatasia Gangadin Page 1 10/6/2009 Cell Molecular Biology Receptor mediated endocytosis system About 30 minute process LDL System o Not energy dependant o Process Binds Coated pit is formed Pinches off Have a coated vesicle Have early endosome Then Late endosome pH is around 5.0 There is Dissociation of ligand and receptor Also called Compartment of uncoupling of receptor ligand CURL o Lysosome LDL transported but not the receptor Is the acidity important? Yes Experiment o Late endosome has pumps o If You block the proton pumps then no uncoupling o Culture the cells in Dilute Ammonium Chloride Takes the pH of 5.0 and drives it up to neutral No uncoupling GTPcrs Gene Protein Coupled Receptors Random Information o 800 known o Most studied o Many are orphans o Many Drugs interact through this pathway G Protein o Can bind GTP or GDP o Like Light switches, can be turned on or off. If On, GTP is bound If Off, GDP is bound Take phosphate off of GTP to go to GDP o Examples Muscarinic Acetylcholine receptor Heart cells Cardiomyocytes Binds to receptor o Causes change to receptor
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Anatasia Gangadin Page 2 10/6/2009 Cell Molecular Biology o Disassociates o If there is an increase in potassium permeability then there is a decrease in frequency of the heart rate
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macrh 10 - Anatasia Gangadin Cell Molecular Biology Page 1...

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