Lecture 11 notes – Psychopathology and Treatment II

Lecture 11 notes – Psychopathology and Treatment II

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Module 51 – Explaining Schizophrenia 51.3 – Brain Abnormalities : a disease of the brain exhibited in symptoms of the mind Symptoms might be biochemical irregularities, hallucinations produced by LSD Dopamine over activity: An excess of dopamine receptors- often six fold, believed that high levels may intensify brain signals producing positive symptoms: Hallucination and paranoia. o Blocking dopamine receptors often lessens positive symptoms o Dopamine blocking drugs have little effect on negative symptoms of withdrawal. o Impaired Glutamate receptors can produce negative symptoms. Abnormal brain activity and anatomy o Low brain activity in frontal lobes o Decline in brain waves that reflect synchronized neural firing in the frontal lobe o Core regions, including the thalamus becoming active during hallucination o Fluid filled areas and shrinkage of cerebral tissue, greater the shrinkage the more severe the thought disorder Low birth weight and birth complications, oxygen deprivation, are known factors
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Lecture 11 notes – Psychopathology and Treatment II

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