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CR9 - Reading for next 2 classes Chapters 5 6 Today focus...

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Reading for next 2 classes Chapters 5, 6 Today focus on 168-189; 196-206
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Objectives What cues get to SCN? Pathways for light, melatonin, activity Details of the light projection
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Hands vs gears Single cells Feedback loops = gears Action potentials = hands Whole organism - Feedback loops = gears - Action potentials = ??? in short term - pacemaker keeps running (hands) in long term - cells become desynchronized (gears?)
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What inputs? • Light • Melatonin • Activity • Temperature Social stimuli
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Eyes necessary for entrainment? Mammals yes Humans -- popliteal? Not in sparrow/lizards etc
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How does light shift? Alters per expression
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How much light? Duration Intensity Saturation
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Rodless AND coneless mice
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rdta = transgenic with loss of rods early in development cl = coneless
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Phase Advance Following Cage Change in Hamster
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  • Winter '09
  • Brody
  • Action Potentials, Circadian rhythm, Activity-Induced Phase Shifts, Duration Intensity Saturation, Slave Oscillators, Hypothetical Diagram

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