CR9 - Oscillators Hypothetical Diagram of Circadian System...

Info iconThis preview shows pages 1–33. Sign up to view the full content.

View Full Document Right Arrow Icon
Reading for next 2 classes Chapters 5, 6 Today focus on 168-189; 196-206
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Objectives What cues get to SCN? Pathways for light, melatonin, activity Details of the light projection
Background image of page 2
Hands vs gears Single cells –Feedback loops = gears –Action potentials = hands Whole organism - Feedback loops = gears Action potentials = ??? in short term - pacemaker keeps running (hands) in long term - cells become desynchronized (gears?)
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
What inputs? •Light •Melatonin •Activity •Temperature •Social stimuli
Background image of page 4
Eyes necessary for entrainment? •Mammals yes •Humans -- popliteal? •Not in sparrow/lizards etc
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
How does light shift? Alters per expression
Background image of page 6
How much light? Duration Intensity Saturation
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 8
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Rodless AND coneless mice
Background image of page 10
rdta = transgenic with loss of rods early in development cl = coneless
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 12
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 14
Background image of page 15

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 16
Background image of page 17

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 18
Background image of page 19

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Phase Advance Following Cage Change in Hamster
Background image of page 20
PRC for Activity-Induced Phase Shifts in Wild- Type Hamsters
Background image of page 21

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 22
Melatonin to entrain •Melatonin is OUTPUT!!! •Can entrain free-running animals –Daily injection –Daily infusion •Useful to the blind??? –Seems to be
Background image of page 23

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Hypothetical Diagram of Circadian System With Slave
Background image of page 24
Background image of page 25

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 26
Background image of page 27

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 28
Background image of page 29

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Background image of page 30
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Oscillators Hypothetical Diagram of Circadian System With Slave Oscillators Zeitgebers affect Phase -- been through that Period -- Aschoffs rule Waveform -- a) splitting and b) photoperiodism de la Iglesia, Meyer and Schwartz, 2003 LL-induced splitting Double plotted, so theres 1 activity bouts/day Double plotted, so theres 2 activity bouts/day Splitting 2 circadian clocks Left/Right SCN/non-SCN Separate cells in SCN Single 12 h clock? Circadian Time (h) 6 12 18 24 30 Phase shift (h)-6-4-2 2 4 LD18:6 LD10:14 Activity ( ! ) Phase shifts Effects of moonlight Increases splitting 3x-4x Increases entrainment to T-cycles Various other effects Summary Eyes are a critical projection to the SCN Contain newly-identified specialized cells that contribute to entrainment Certainly other pathways are quite important Much work to be done to effectively/efficiently entrain humans...
View Full Document

This note was uploaded on 04/14/2009 for the course BIMM 116 taught by Professor Brody during the Winter '09 term at UCSD.

Page1 / 33

CR9 - Oscillators Hypothetical Diagram of Circadian System...

This preview shows document pages 1 - 33. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online