CR8 - Restoration of Activity Rhythms by Wild-Type Hamster...

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Reading for today and next week •Chapters 5, 6 •Today focus on 168-189; 196-201 •Recommend paper on website (discussed in lecture) Objectives •How to establish that SCN is “the clock” •Understand various neurobiological techniques •Relate behavioral properties of clocks to their physiology Three lectures on mammals
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2DG Autoradiographs Showing Uptake in Rat SCN (upper figures) and Staining of SCN (bottom): Subjective Day (A,B) and Subjective Night (C,D) Suprachiasmatic Nuclei Rat drinking rhythm after blinding (top) and SCNx (bottom)
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2DG Autoradiographs Showing Uptake in Rat SCN (upper figures) and Staining of SCN (bottom): Subjective Day (A,B) and Subjective Night (C,D) Multiunit Activity in Hypothalamic Island Containing SCN and in Caudate Nucleus of Rat Brain Multiunit Activity in Hypothalamic Island (Containing SCN) and in Dorsal Raphae of Rat Brain
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Restoration of Activity Rhythm by SCN Transplant From Wild-Type Hamster to SCN-Ablated Tau-Mutant Hamster
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Unformatted text preview: Restoration of Activity Rhythms by Wild-Type Hamster SCN Transplant Into Tau-Mutant Hamster With Partial Ablation of SCN Hypothetical Diagram of Circadian System With Slave Oscillators 20 26 What happens to these cells in DD? Summary •SCN is the mammalian pacemaker, although not the only oscillator -- more on this in later classes •Individual cells derive clock functions from molecular feedback loops. Neuronal firing rhythm is one important OUTPUT of a cell’s clock •Cells have to be synchronized or everything would be a mess. Genes only get you so far. Summary •The neural firing rhythm is probably not essential for cells to tick-tock, but may be how cells stay synchronized, and thus be essential gear of the organism’s clock Double plotted, so there’s 1 activity bouts/day Double plotted, so there’s 2 activity bouts/day...
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This note was uploaded on 04/14/2009 for the course BIMM 116 taught by Professor Brody during the Winter '09 term at UCSD.

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CR8 - Restoration of Activity Rhythms by Wild-Type Hamster...

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