CR15 - Nan-190 Serotonin antagonist Non-pharmaceutical Dim...

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1 • Symptoms • Causes • Treatments • Clocks In Transit Awaken Sleep * * ! ! $ • Daytime fatigue • Insomnia • Changes in appetite • Digestive problems • Headaches • Memory deficits • Emotional lability • Disorientation Symptoms
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2 Effects of Chronic Jetlag • Cognitive deficits Delayed Matching to Sample Visual Spatial Task • Temporal lobe atrophy • Tumor Progression • Fatality in aged mice Awaken Sleep * * ! ! $ • Not Just Travel – Crossing Timezones • Entrained to local time – Initial mismatch – Gradual re-entrainment • Average 1.3 h /day – Sunlight in new time zone Causes
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3 Jetlag Without the Jet Reddy et al, 2002 Delays vs Advances Antidromic Re-entrainment – Wrong Direction Some just alleviate symptoms Some can speed re-adjustment – Correct Timing is Critical “Treatments”
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4 Preflight Plan? – Shift to new time zone before departure Postflight Plan? – Zeitgeber timing upon arrival Planning Your Trip http://www.bodyclock.com/ Other Agents Viagra – PDE inhibitor – Increase in cGMP
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Unformatted text preview: Nan-190 Serotonin antagonist Non-pharmaceutical Dim light at night 5 Clocks in Transit: Wheres the lag in jetlag? Many clocks in brain and body How does the system adjust? SCN vs other clocks SCN = Oscillator Complex How does the SCN adjust? Population dynamics Awaken Sleep * * ! ! $ & Glowing Cells Bioluminescence Rhythms Luciferase controlled by clock gene PER2::Luc Knockin Mouse Monitor clock gene rhythms SCN, Peripheral tissues, Other (Relatively) noninvasive, non-toxic 6 How does the system adjust? Luminometry Photomultiplier Tubes Light Levels Tissue Specific Rate of Re-Entrainment Internal Synch Within Body Disrupted 7 How does the SCN adjust? High resolution imaging Single Cell Rhythms Regional Differences Regional Differences in Shifting Dynamics Internal Synch Within SCN Disrupted...
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CR15 - Nan-190 Serotonin antagonist Non-pharmaceutical Dim...

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