CR12 - – Cycled light from 36 weeks • Outcomes Preemies...

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Objectives Learn about the development of clock function Understand clock interaction between mother and offspring Consider consequences of clock function for development
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Three timelines When does – clock start ticking? – entrainment begin? – output become rhythmic?
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DAY NIGHT BABOON NEWBORNS
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2-DG in Fetal SCNs
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Sladek, PN Per1 Per2 Cry Bmal1 Clock
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Varies Varies Other outputs postnatal 10-20 early postnatal? Melatonin postnatal 7-15 prenatal Light entrainment late-gestation mid-gestation SCN fxn Rodents Primates Pineal NAT Rhythm in Rat Pups: Influence of Mother
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Pineal NAT in 10-Day Rats 2-DG in Fetal SCNs
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2-DG in fetal SCNs (rats) Activity Rhythms of Hamsters Born to Rhythmic or Arrhythmic Mothers Moms Pups
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Conceptual Model of Maternal-Fetal Communication of Circadian Phase in Rodents Phase Distributions of Hamster Pups Born to Mothers That Received Timed Melatonin Injections During Gestation
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Preemies Born < 31 weeks • Treatments – Near darkness (5-10 lux) – Cycled light from 32 weeks (200 lux)
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Unformatted text preview: – Cycled light from 36 weeks • Outcomes? Preemies • Born < 31 weeks • Treatments – Near darkness (5-10 lux) – Cycled light from 32 weeks (200 lux) – Cycled light from 36 weeks • Outcome at 45 weeks ( = 7 weeks normal postnatal) WEEKLY WEIGHT GAIN – ND = 200 grams – CL32 = 330 grams – CL36 = 380 grams Another example • Photoperiodism – Siberian hamsters – Critical daylength ~13-14 h – Happens twice per year • In fall, associated with inhibition • In spring, associated with stimulation small 14L Pinx + 6 h MEL for last 3 days big 14L Pinx + 10 h MEL for last 3 days big 14L Pinx 16L, 14L etc big 14L 12L small 14L 16L small 12L 12L big 16L 16L Gonad at D30-35 Postnatal Prenatal Summary • Circadian rhythmicity apparent in the womb • At least some is maternal in origin • Redundant cues from the mother set the phase of offspring clocks • Clear examples of rhythms for later development...
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