CR12 - Cycled light from 36 weeks Outcomes? Preemies Born...

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Objectives • Learn about the development of clock function • Understand clock interaction between mother and offspring • Consider consequences of clock function for development
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Three timelines • When does – clock start ticking? – entrainment begin? – output become rhythmic?
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DAY NIGHT BABOON NEWBORNS
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2-DG in Fetal SCNs
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Sladek, PN Per1 Per2 Cry Bmal1 Clock
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Varies Varies Other outputs postnatal 10-20 early postnatal? Melatonin postnatal 7-15 prenatal Light entrainment late-gestation mid-gestation SCN fxn Rodents Primates Pineal NAT Rhythm in Rat Pups: Influence of Mother
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Pineal NAT in 10-Day Rats 2-DG in Fetal SCNs
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2-DG in fetal SCNs (rats) Activity Rhythms of Hamsters Born to Rhythmic or Arrhythmic Mothers Moms Pups
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Conceptual Model of Maternal-Fetal Communication of Circadian Phase in Rodents Phase Distributions of Hamster Pups Born to Mothers That Received Timed Melatonin Injections During Gestation
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Preemies • Born < 31 weeks • Treatments – Near darkness (5-10 lux) – Cycled light from 32 weeks (200 lux)
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Unformatted text preview: Cycled light from 36 weeks Outcomes? Preemies Born &lt; 31 weeks Treatments Near darkness (5-10 lux) Cycled light from 32 weeks (200 lux) Cycled light from 36 weeks Outcome at 45 weeks ( = 7 weeks normal postnatal) WEEKLY WEIGHT GAIN ND = 200 grams CL32 = 330 grams CL36 = 380 grams Another example Photoperiodism Siberian hamsters Critical daylength ~13-14 h Happens twice per year In fall, associated with inhibition In spring, associated with stimulation small 14L Pinx + 6 h MEL for last 3 days big 14L Pinx + 10 h MEL for last 3 days big 14L Pinx 16L, 14L etc big 14L 12L small 14L 16L small 12L 12L big 16L 16L Gonad at D30-35 Postnatal Prenatal Summary Circadian rhythmicity apparent in the womb At least some is maternal in origin Redundant cues from the mother set the phase of offspring clocks Clear examples of rhythms for later development...
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CR12 - Cycled light from 36 weeks Outcomes? Preemies Born...

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