all problem sets up to lect 12

all problem sets up to lect 12 - BIPN 144- Developmental...

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BIPN 144- Developmental Neuroscience Week 1 – Background, Gastrulation and Induction   Key Terms Central Nervous System -  Peripheral Nervous System -  Autonomic Nervous System  o Sympathetic - o Parasympathetic - Sensory afferents -  Motor efferents - Dendrite  -  axon – Synapse Model Species Central Dogma of Biology :  o DNA  RNA Protein o DNA and RNA structure and  location – mRNA and cDNA  relationship in-situ hybridization o Transcription (factors) – Reverse transcription o Translation  – Background
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Developmental neuroscience – how does 1 cell create a trillion neurons making 10^16 connections (synapses) o 100 X more glial cells than neurons Neurons are specialized cells that allow unidirectional flow of information. Logic of Experimentation Question Method Findings Interpretation What makes the following species so useful in models o C. elegans - o Drosophila - o Zebrafish - o Frogs - o Chick -
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o Mice –  Proteins can be classed  by location:  secreted, membrane, Cytoplasmic, nuclear and function: transcriptional/translational factors, ligands, receptors, cell- cycle proteins, cytoskeleton proteins "Nothing in Biology Makes Sense Except in the Light of Evolution". – Geneticist and  Evolutionary Biologist Theodosius Dobzhansky. Eggs are polar and contains 2 sides : _____________ and _____________ o Which side contains the nutrients-  o Which side contains the embryo –  Egg divides to form a hollow sphere called _____________ o Inner cavity known as blastocoel ___________ = rearrangement of cells to generate 3 germ layers o 1. Ectoderm - o 2. Mesoderm - o 3. Endoderm –  Gastrulation      begins with invagination which takes place at the  dorsal lip o Gastrulation video #5 at   http://www.pbs.org/wgbh/nova/miracle/program_adv.html And also  http://faculty.virginia.edu/shook/ShowMovies/Xenopus_Gastrulation.mov o What germ layer makes up the dorsal lip o Spemann removed the dorsal lip from an embryo and cultured the cells prior to and  following gastrulation. What were the observed results? What does this mean? Spemann and Mangold grafting experiment. o Dorsal lip from a donor embryo was removed and grafted onto a host embryo of different  pigmentation.  What were the observed results?
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Why were embryos of various pigmentations used and what did it prove? What facilitates the formation of a mesoderm? Neural Inducers can be direct and indirect. How?
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This note was uploaded on 04/14/2009 for the course BIPN 144 taught by Professor Jin during the Winter '08 term at UCSD.

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all problem sets up to lect 12 - BIPN 144- Developmental...

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