Lecture 1

Lecture 1 - General information Neurodevelopment BIPN 144...

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Neurodevelopment BIPN 144 Professor Yishi Jin 2418 Bonner Hall Office Hours - Tu 9-11 am General information Poplawski • Contact information: see syllabus (WebCT) • Textbook: “Development of the Nervous System” by Sanes, Reh, Harris (2nd edition) • Lecture outlines (WebCT): Powerpoint pdf • Discussion sections: attendance is not mandatory, will provide problem sets and discussions • 2 midterms (each is worth 25% of grade) • 1 final (50% of your grade, cumulative): Mar 17 7-9:59pm • No make-up exams • No cell phones, pagers, allowed in lecture room General Information Introduction to Neurodevelopment • The study of neural development draws on both neuroscience and developmental biology to describe the cellular and molecular mechanisms by which complex nervous systems emerge during embryonic development and throughout life.
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Major components of the nervous system Central vs. peripheral nervous system Brain Spinal cord CNS Sensory afferents Motor and autonomic efferents (motor control and neural control of organs/glands) PNS Anatomical directions DORSAL/VENTRAL:back/belly ROSTRAL/CAUDAL: nose/tail (ANTERIOR/POSTERIOR) (front/back) MEDIAL/LATERAL: midline/periphery The Adult Cerebral Cortex 10 12 neurons each making 100-10,000 synaptic connections 100 X more glia cells
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Prenatal Growth of the Human Brain Neurons are highly specialized cells that allow unidirectional flow of information S. Ramon y Cajal 1891 Neurons assume different morphology and are arranged orderly Neural Induction Regionalization Neurogenesis Migration Specification Differentiation Axon guidance Dendritic growth Target selection Neuronal death Synapse formation Synapse refinement Experience and circuit modification Regeneration Adult neurogenesis Stem Cells Topics Covered:
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Logic of experimentation • The major question(s) addressed by the study • The methods employed to answer the question(s) • The main findings (results) of the study • The interpretation of the findings (1) Observation and Description 1) Histology: Labeling individual neurons in
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Lecture 1 - General information Neurodevelopment BIPN 144...

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