Lecture 4

Lecture 4 - Neurodevelopment BIPN 144#4 Professor Yishi Jin...

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Unformatted text preview: Neurodevelopment BIPN 144 #4 Professor Yishi Jin 2418 Bonner Hall Office Hours - Tu 9-11 am Jan 19: Happy MLK day! Jan 26: midterm I--neurogenesis cell cycle: generating neurons birth-dating: when neurons are born clonal analysis: neuronal lineage--radial migration in cortex: “inside-out” layer formation radial glia Reelin and its role Last time-in the cerebral cortex, neurons fail to migrate to their proper position, forming an outside-in cortex The Reeler Mutant Mouse-mutant mouse has motor problems-in cerebellum, Purkinje cells are reduced in number and form clusters rather than a single layer-the defective molecule in reeler mouse is “ Reelin ”, a large extracellular glycoprotein and is expressed by Cajal-Retzius cells in the Marginal Zone Extracellular matrix is made of proteins, many of which are glycosylated, mediates cell-cell, cell-matrix interactions, supports cell shape, cell movement, cell adhesion… Neurogenesis and Migration in CNS (1) Radial Migration Depends on radial glia Abnormal in Reelin mutants (2) Tangential Migration Does not depend on radial glia Normal in Reelin mutants Two broad classes of cortical neurons Pyramidal excitatory neurons Secrete glutamate Generated from ventricular zone Undergo radial migration Inhibitory interneurons Secrete GABA Generated from LGE (lateral ganglion eminence) Do not undergo radial migration GABAergic Interneurons are generated from LGE and undergo tangential migration Fig.3.20 DNS Pyramidal excitatory neurons LGE Clonal analysis inhibitory neurons Tangential migration depends on Dlx genes Neurogenesis and Migration in CNS (1) Radial Migration Depends on radial glia Abnormal in Reelin mutants (2) Tangential Migration Does not depend on radial glia Normal in Reelin mutants Two broad classes of cortical neurons Pyramidal excitatory neurons...
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Lecture 4 - Neurodevelopment BIPN 144#4 Professor Yishi Jin...

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