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Lecture 5 - Neurodevelopment BIPN 144 Lecture 5 Professor...

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Neurodevelopment BIPN 144 Lecture 5 Professor Yishi Jin 2148 Bonner Hall Office Hours - Tu 9-11 am MIDTERM #1 Jan 26 Last time M --CNS: radial migration and tangential migration --PNS: neural crest cells origin from dorsal neural tube long range migration generate many types of neurons --Neural fate specification and differentiation C. elegans invariant cell lineage single neuron resolution “function-based” genetic screen approach “transcription” regulation of neuron fate Generation and specification of touch neuron Cell lineage Precursor: migration depends on Wnt Unc-86 (transcription factor) acts early in lineage and controls cell-division pattern Mec-3 (transcription factor) acts late in lineage and controls expression of genes involved in “differentiation” Differentiation of touch neurons requires expression of genes such as channels, microtubules microtubules --MEC-3 controls the expression of “differentiation genes”
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HSN wild type A few eggs inside HSN neuon killed Many eggs inside “Egg-laying defective” --screen for “Egl” mutants: genes control HSN development A transcriptional network regulates HSN development --UNC-86 regulates differentiation genes in HSN Summary C. elegans touch neurons and HSN neurons fates are determined by a combination of transcription factors that are expressed in a lineage specific manner Same transcription factor can function at different
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