Lecture 3

Lecture 3 - Last time Neurodevelopment BIPN 144 Lecture 3...

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Neurodevelopment BIPN 144 Lecture 3 Professor Yishi Jin 2418 Bonner Hall Office Hours - Tu 9-11 am Last time -Morphogens: encode positional information and act in a concentration-dependent manner -Anterior-posterior axis patterning Drosophila-- A/P segmentation mutants, “homeobox” transcription factors Hindbrain-- rhombomeres, Hox genes, mouse knockout Regionalization -- organizer regions in head and tail, and morphogens (e.g. RA, Wnt etc) Dorsal-Ventral Patterning Neurulation Results in Formation of the Neural Tube - D/V polarity arises through interaction between surrounding non-neuronal tissue and the neural tube. Kandel. Schwartz, and Jessell 2000
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notochord is necessary and sufficient for ventral patterning control “Loss of function” “Gain of function” Figure 2.23, DNS Notochord is mesoderm derived structure. Sonic hedgehog (Shh): a secreted factor that is homologous to Drosophila protein Hedgehg (hh) and patterns the ventral neural tube --expressed in notochord when D/V axis is forming -also expressed in floorplate Figure 2.23, DNS Figure 2.25, DNS Cell culture assay: expression of SHH alone is sufficient to induce ventral neural tissues different classes of neurons within the developing spinal cord express different sets of transcription factors GREEN -- left, RED--right, YELLOW -- overlap Figure 2.24, DNS
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Multiple morphogens pattern the D-V axis in a combinatorial manner Figure 2.28, DNS The vertebrate brain and spinal cord develop from the neural tube The mechanisms that initially set up the anterio-posterior or dorsal-ventral axes of the embryo also control regional development of the nervous system Morphogens –factors that inform neighboring cells of their location and fate. Combinatorial action of morphogens results in selected gene expressions, via transcription factors, in cells located at different regions along A/P and D/V axis CNS Patterning III. Neurogenesis and Migration • Neurogenesis – Cell-cycle and cell proliferation – “birth-dating” for labeling progenitor cells • Migration – Cerebral cortex - Radial glia - Molecular basis Terminology • Proliferation -- increase in cell number by cell division
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This note was uploaded on 04/14/2009 for the course BIPN 144 taught by Professor Jin during the Winter '08 term at UCSD.

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Lecture 3 - Last time Neurodevelopment BIPN 144 Lecture 3...

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