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mcII08e2 - MEDICINAL CHEMISTRY II EXAM#2 Name Med Chem...

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MEDICINAL CHEMISTRY II EXAM #2 April 11, 2008 Name Med. Chem Number SECTION A. Answer each question in this section by writing the letter corresponding to the best answer on the line provided (2 points each; 26 points total) 1. The drug illustrated below: I Is used to treat schizophrenia and bipolar disorder II Is the major metabolite formed from Risperidone III Is Paliperidone a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 2. The drug illustrated below: HN N O O CH 2 CH 3 I Is used to treat grand mal seizures II Must be metabolized to an imide before becoming active as an antiepileptic drug III Is used to treat petit mal seizures 3. The drug illustrated below: N H N S CH 3 N N CH 3 I Produces agranulocytosis as a major side effect II Treats only the positive aspects of schizophrenia III Can undergo metabolism by N-demethylation to form a secondary amine and formaldehyde
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2 4. The drug illustrated below: I Forms a trans -10,11-dihydrodiol as a major metabolite II Is used mainly as a tricyclic antidepressant III Contains a primary amine functional group N O NH 2 5. The drug illustrated below: I Is rapidly metabolized by aromatic hydroxylation II Undergoes metabolism by oxidation of the alcohol at the 4-position of the piperidine ring to a ketone III Is used to treat some of the symptoms of Tourette’s Syndrome a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 6. The drug illustrated below: I Blocks the D 2 receptor II Is released slowly from fatty deposits in the body and undergoes metabolic hydrolysis to form fluphenazine and decanoic acid III Is a powerful antipsychotic used to treat schizophrenia
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