mcII08e2

mcII08e2 - MEDICINAL CHEMISTRY II EXAM #2 April 11, 2008...

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MEDICINAL CHEMISTRY II EXAM #2 April 11, 2008 N a m e M e d . C h e m N u m b e r SECTION A. Answer each question in this section by writing the letter corresponding to the best answer on the line provided (2 points each; 26 points total) 1. The drug illustrated below: I Is used to treat schizophrenia and bipolar disorder II Is the major metabolite formed from Risperidone III Is Paliperidone a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 2. The drug illustrated below: HN N O O CH 2 CH 3 I Is used to treat grand mal seizures II Must be metabolized to an imide before becoming active as an antiepileptic drug III Is used to treat petit mal seizures a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 3. The drug illustrated below: N H N S CH 3 N N CH 3 I Produces agranulocytosis as a major side effect II Treats only the positive aspects of schizophrenia III Can undergo metabolism by N-demethylation to form a secondary amine and formaldehyde a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 1
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2 4. The drug illustrated below: I Forms a trans -10,11-dihydrodiol as a major metabolite II Is used mainly as a tricyclic antidepressant III Contains a primary amine functional group N O NH 2 a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 5. The drug illustrated below: I Is rapidly metabolized by aromatic hydroxylation II Undergoes metabolism by oxidation of the alcohol at the 4-position of the piperidine ring to a ketone III Is used to treat some of the symptoms of Tourette’s Syndrome a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 6. The drug illustrated below: I Blocks the D 2 receptor II Is released slowly from fatty deposits in the body and undergoes metabolic hydrolysis to form fluphenazine and decanoic acid III Is a powerful antipsychotic used to treat schizophrenia a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer
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3 7. The drug illustrated below: CO 2 H H 2 N Cl I Undergoes metabolism to form GABA II Is used to treat spasticity resulting from multiple sclerosis or trauma to the spinal cord III Is an agonist for the GABA B receptor a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 8. The drug illustrated below: I Is used to treat grand mal seizures only II Is a prodrug III Is used to treat petit mal seizures a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 9. The drug illustrated below: I Is used to treat nausea and vomiting II Is promethazine hydrochloride III Is used to treat schizophrenia and bipolar disorder a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 10. The drug illustrated below is: I Is used to treat petit mal seizures in children II Inhibits carbonic anhydrase III Is Zonisamide a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer
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4 11. The drug illustrated below: I Possesses no anticholinergic activity II
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This note was uploaded on 04/14/2009 for the course 663 701 taught by Professor Arnold,e. during the Spring '09 term at Rutgers.

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mcII08e2 - MEDICINAL CHEMISTRY II EXAM #2 April 11, 2008...

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