1Medicinal Chemistry 410 Exam #1 February 29, 2008 Name: Med. Chem. # Part I. (75 Points) There are 50 multiple choice questions worth 1.5 points each (75 Points). Please use the Scantron Sheet provided. 1. The anticancer drug illustrated below: NH2NH2PtOOOOHHIreacts with DNA primarily forming an interstrand cross link. II exhibits greater nephrotoxicity than cisplatin.IIIprimarily forms adducts with a single strand of helical DNA.a I only b III only c I and II only d II and III only e I, II, and III Answer 2. The drug illustrated below: SOONHH2NNOCH3Iis a false substrate that mimics p-aminobenzoic acid. II inhibits the De Novo synthesis of folates in bacteria.IIIis used to treat bacterial urinary tract infections (UTI’s).a.I only b.III only c.1 and II only d.II and III only e.I, II, and III Answer 3.The drug illustrated below has which of the following properties: NOCH3HHHNONOCH3CCH3CNSH2NSO3NaOOIis recognized for its effectiveness against gram (-) bacteria II cross allergenicity in patents sensitive to pencillins is fully expected.IIIis used orally.a I only b III only c I and II only d II and III only e I, II, and III Answer
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