mcII08e1

mcII08e1 - 1 Medicinal Chemistry 410 Exam #1 February 29,...

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1 Medicinal Chemistry 410 Exam #1 February 29, 2008 N a m e : Med. Chem. # Part I. (75 Points) There are 50 multiple choice questions worth 1.5 points each (75 Points). Please use the Scantron Sheet provided. 1. The anticancer drug illustrated below: NH 2 NH 2 Pt O O O O H H I reacts with DNA primarily forming an interstrand cross link. II exhibits greater nephrotoxicity than cisplatin. III primarily forms adducts with a single strand of helical DNA. a I only b III only c I and II only d II and III only e I, II, and III Answer 2. The drug illustrated below: S O O N H H 2 N N O CH 3 I is a false substrate that mimics p -aminobenzoic acid. II inhibits the De Novo synthesis of folates in bacteria. III is used to treat bacterial urinary tract infections (UTI’s). a. I only b. III only c. 1 and II only d. II and III only e. I, II, and III Answer 3. The drug illustrated below has which of the following properties: N O CH 3 H H HN O N O C H 3 C 3 C N S H 2 N SO 3 Na O O I is recognized for its effectiveness against gram (-) bacteria II cross allergenicity in patents sensitive to pencillins is fully expected. III is used orally. a I only b III only c I and II only d II and III only e I, II, and III Answer
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2 4. The drug illustrated below: N N N N NH 2 O P O HO OH I is associated with chain termination in the synthesis of viral DNA. II is converted to a mimic of 2’-deoxyadenosine triphosphate. III is resistant in viruses with a deficiency in viral thymidine kinase. a I only b III only c I and II only d II and III only e I, II, and III Answer 5. The drug illustrated below: N CH 2 CH 2 CH 2 C Cl Cl O OH I is too unstable for oral administration. II primarily cross-links two individual DNA strands. III is a bifunctional alkylating agent. a I only b III only c I and II only d II and III only e I, II, and III Answer 6. The drug illustrated below: N O N H H O S CO 2 C H 2 H N O N S H 2 N N CH 3 H 3 C COOH I is NOT orally active. II is β -lactamase resistant. III inhibits bacterial cell wall synthesis by inhibiting penicillin binding protein ( a transpeptidase). a I only b III only c I and II only d II and III only e I, II, and III Answer 7. The drug illustrated below: I . is a potent antifungal agent. II binds to the heme portion of a specific cytochrome P450. III is an aromatase inhibitor. a I only b III only c I and II only d II and III only e I, II, and III Answer
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3 8. The drug illustrated below: N N O O H 3 CH 2 C OH O O H 2 C CH 3 N N O I is a mitotic spindle poison. II is a substrate for the efflux transporters MDR1 and BCRP. III stabilizes the cleaved complex formed from topoisomerase I and DNA. a I only b III only c I and II only d II and III only e I, II, and III Answer 9. The drug illustrated below: N N NH 2 NH 2 H 2 C H 3 CO OCH 3 OCH 3 I inhibits dihydrofolate reductase in bacteria.
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This note was uploaded on 04/14/2009 for the course 663 701 taught by Professor Arnold,e. during the Spring '09 term at Rutgers.

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mcII08e1 - 1 Medicinal Chemistry 410 Exam #1 February 29,...

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