mcII07e2

mcII07e2 - MEDICINAL CHEMISTRY II EXAM #2 March 23, 2007...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
1 MEDICINAL CHEMISTRY II EXAM #2 March 23, 2007 Name Med. Chem Number SECTION A. Answer each question in this section by writing the letter corresponding to the best answer on the line provided (2 points each; 50 points total) 1. The drug illustrated below: CO 2 H O CH 3 O I Irreversibly inhibits cyclooxygenase II Undergoes metabolic hydrolysis to salicyclic acid III Is an organic acid that can irritate the stomach a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 2. The drug illustrated below is: N C O OH CH 2 CH 2 H Cl C C N I Can readily enter the CNS because it is non-polar II Is used primarily as an analgesic during childbirth III Is administered with atropine for control of diarrhea a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 3. The drug illustrated below: O N CH 3 H H H 3 CO OH H 2 PO 4 I Has good antitussive activity II Can undergo metabolic conversion into morphine III Has no affinity for μ-receptors because of the 7,8- double bond a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 4. The drug illustrated below: H 2 N COCH 2 CH 2 O N CH 2 CH 3 CH 2 CH 3 H Cl I Is susceptible to environmental oxidation at the amino group and should be stored under nitrogen II Is metabolized rapidly by ester hydrolysis III Is usually administered together with atropine to reduce its abuse potential a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 5. The drug illustrated below: H N CO 2 H CH 3 CH 3 I Is likely to cause methemoglobinemia in susceptible patients II Is a salicylate NSAID III Is used to treat mild to moderate pain a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 6. The drug illustrated below: H 2 C N CH 3 CH 3 H HO H 3 CO H Cl I Is a cis -1,2-disubstituted cyclohexane derivative II Contains the necessary pharmacophore for a μ-agonist and is used to treat pain III Is a trans -1,2-disubstituted cyclohexane derivative a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 7. The drug illustrated below: CH 2 CH 2 N CH 2 OCH 3 N C O CH 2 CH 3 H S CH 2 CO 2 HO CO 2 H CH 2 CO 2 H I Is a salt of citric acid II Is an extremely potent analgesic III Can be used to induce and maintain anesthesia during surgery a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer
Background image of page 2
3 8. The drug illustrated below: S N N N H 3 C CH 3 CH 3 CH 3 Cl I Can be used at high doses as an antidote to cyanide poisoning II Is used at high doses for treating methemoglobinemia III Is used to treat an overdose of acetaminophen a) I only b) III only c) I and II only d) II and III only
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 04/14/2009 for the course 663 701 taught by Professor Arnold,e. during the Spring '09 term at Rutgers.

Page1 / 13

mcII07e2 - MEDICINAL CHEMISTRY II EXAM #2 March 23, 2007...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online