mcII07e1

mcII07e1 - MEDICINAL CHEMISTRY II EXAM #1 February 16, 2007...

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MEDICINAL CHEMISTRY II EXAM #1 February 16, 2007 N a m e M e d . C h e m N u m b e r SECTION A. Answer each question in this section by writing the letter corresponding to the best answer on the line provided (2 points each; 50 points total) 1. The drug illustrated below: N N O O O H CH 3 CH 2 H I Is a 1H,3H,5H-pyrimidine-2,4,6-trione derivative II Is used to treat grand mal seizures III Is an ultra-short acting barbiturate used to induce general anesthesia a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 2. The drug illustrated below is: N CH 2 CH 2 CH 2 N CH 3 H I Is used mainly to treat schizophrenia II Contains three aromatic rings III Is used to treat depression a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 3. The drug illustrated below: F C O CH 2 CH 2 CH 2 N OH Cl I Is metabolized mainly by aromatic hydroxylation II Can be used to treat the vocal utterances and tics associated with Tourette’s syndrome III Works by blocking dopamine D2 receptors a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer
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2 4. The drug illustrated below: O O O O O CH 3 CH 3 H C 3 CH 3 CH 2 O S O O NH 2 I Is used to treat partial seizures II Is used as part of a weight loss regimen III Is an inhibitor of pancreatic lipase a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 5. The drug illustrated below: CHS O CH 2 C O NH 2 I Is used by special operations soldiers to help keep them awake for prolonged periods of time II Is a CNS stimulant III Is an antihistamine with sedative side effects a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 6. The drug illustrated below: N N N Cl O O H O N N CH 3 I Can undergo metabolism by N-oxidation on the pyrazine ring II Is used to treat insomnia III Contains a carbamate functional group a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer
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3 7. The drug illustrated below: H N O N N Cl Cl O I Is used to treat schizophrenia II Is administered only once a day III Is an agonist for ω -1 receptors a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 8. The drug illustrated below: F 3 C C CH 2 CH 2 CH 2 CH 2 N O CH 2 CH 2 NH 3 OCH 3 CO 2 H CO 2 H I Is shown as a salt with (E)-2- butenedioic acid II Cannot enter the CNS because it is always charged III Is used to treat obsessive-compulsive disorder H a) I only b) III only c) I and II only d) II and III only
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mcII07e1 - MEDICINAL CHEMISTRY II EXAM #1 February 16, 2007...

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