mcII06e2

McII06e2 - MEDICINAL CHEMISTRY II EXAM#2 Name Med Chem Number SECTION A Answer each question in this section by writing the letter corresponding to

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MEDICINAL CHEMISTRY II EXAM #2 March 24, 2006 N a m e M e d . C h e m N u m b e r SECTION A. Answer each question in this section by writing the letter corresponding to the best answer on the line provided (2 points each; 50 points total) 1. The drug illustrated below: H N C O CH 3 CH 3 N H CH 2 CH 2 CH 3 Cl H I Is an R-enantiomer II Is an injectible local anethetic III Is an S-enantiomer a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 2. The drug illustrated below is: O N CH 3 H H H 3 CO OH H 2 PO 4 I Is effective when given orally for treating moderate pain and coughing II Undergoes extensive first-pass metabolism when given orally which limits its effectiveness III Behaves as an antagonist at µ -receptors because of the double bond between the 7- and 8-positions a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 3. The drug illustrated below: C CH 2 CH CH CH 3 CH 2 CH 3 N CH 3 H 3 C O C
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2 4. The drug illustrated below: O O OH CO 2 H I Is a topical local anesthetic used to treat sunburn II Will irreversibly inhibit cyclooxygenase in platelets III Undergoes metabolism to two molecules of salicyclic acid a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 5. The drug illustrated below: O H 3 C CH 2 CH 2 C O CH 3 I Is used to treat arthritis II Must be metabolized to 6-methoxy-2- naphthylacetic acid before it can inhibit cyclooxygenase III Is used as a topical local anesthetic on mucous membranes a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 6. The drug illustrated below: N O CH 2 CH 2 CH 2 CH 3 O H N CH 2 CH 2 N CH 2 CH 3 CH 2 CH 3 I Is used topically on skin as a local anesthetic II Is long-acting due to slow metabolism III Is an isoquinoline derivative a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 7. The drug illustrated below: CCH 2 CH 2 N C N C O CH 2 CH 3 H Cl O H 3 CO O OCH 3 I Has a short duration of action because of rapid hydrolysis of one of the methyl ester groups II Is a potent µ -agonist III Can cause respiratory depression a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer
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3 8. The drug illustrated below: N N CF 3 S H 2 N O O H 3 C I Is a selective cyclooxygenase II inhibitor II Contains an imidazole ring III Is a uricosuric agent used to treat chronic gout a) I only b) III only c) I and II only d) II and III only e) I, II, and III
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This note was uploaded on 04/14/2009 for the course 663 701 taught by Professor Arnold,e. during the Spring '09 term at Rutgers.

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McII06e2 - MEDICINAL CHEMISTRY II EXAM#2 Name Med Chem Number SECTION A Answer each question in this section by writing the letter corresponding to

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