mcII06e1

mcII06e1 - MEDICINAL CHEMISTRY II EXAM #1 February 17, 2006...

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MEDICINAL CHEMISTRY II EXAM #1 February 17, 2006 N a m e M e d . C h e m N u m b e r SECTION A. Answer each question in this section by writing the letter corresponding to the best answer on the line provided (2 points each; 50 points total) 1. The drug illustrated below: N O H 3 C O NH HN CH 2 I Is a substrate for monoamine oxidase II Inhibits monoamine oxidase III Is used as an appetite suppressant a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 2. The drug illustrated below is: CC F F F F H O C F F H I Is metabolized to inorganic bromide that can damage the kidney II Is highly flammable III Is a general anesthetic that is not extensively metabolized a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 3. The drug illustrated below: N N F N O CH 3 CO 2 CH 2 CH 3 I May cause seizures II Is used to reverse the effects of an overdose of benzodiazepines III Is a competetive antagonist for benzodiazepine receptors a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer
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2 4. The drug illustrated below: H N N N N S O Cl H Cl I Is used primarily to treat schizophrenia II Incorporates a benzothiazole within its structure III Is used primarily to treat depression a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 5. The drug illustrated below: N H N CH 3 CH 2 O O CH 3 I Is used to treat petit mal seizures II Is a long-acting barbiturate III Is used to treat grand mal seizures a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 6. The drug illustrated below: N CH 3 CH 3 CH 2 I Is too bulky to enter the CNS II Has decreased excitatory properties as compared to dextroamphetamine III Is used as an appetite suppressant a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 7. The drug illustrated below: O N H CH 3 F 3 C I May be used to treat Obsessive-Compulsive Disorder II Is used primarily as a general anesthetic because of its high lipophilicity III Selectively inhibits the reuptake of norepinephrine a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer
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3 8. The drug illustrated below: N N Cl S CH 2 CF 3 F I Undergoes metabolism to give a lactam II Selectively inhibits the benzodiazepine ω 1 receptor III Is used to treat insomnia a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 9. The drug illustrated below: N CH 3 H H O H 3 C H Cl I Is used to treat Attention Deficit with Hyperactivity Disorder in children and adults II Contains a chiral center with (R)- configuration III Is a potent CNS stimulant
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mcII06e1 - MEDICINAL CHEMISTRY II EXAM #1 February 17, 2006...

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