mcII05e2

mcII05e2 - MEDICINAL CHEMISTRY II EXAM #2 April 1, 2005...

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MEDICINAL CHEMISTRY II EXAM #2 April 1, 2005 N a m e M e d . C h e m N u m b e r SECTION A. Answer each question in this section by writing the letter corresponding to the best answer on the line provided (2 points each; 50 points total) 1. The drug illustrated below: O CH 3 CH 2 CH 2 CH 2 C O CH 2 CH 2 N H Cl I Is a benzoate ester local anesthetic II Cannot penetrate into neurons because it is 100% charged at all pH values III Is used as a topical local anesthetic on mucous membranes and is sold over the counter a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 2. The drug illustrated below is: O HO N CH 3 H O H I Can be addicting II Is a µ -agonist III Is used to treat pain a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 3. The drug illustrated below: O HO N CH 2 OH O H CH Cl H CH 2 I Can reverse respiratory depression resulting from an overdose of opioid narcotics II Is most effective when given orally III Is a potent µ -agonist a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer
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2 4. The drug illustrated below: HO O CO 2 CH 3 HO CH 3 I Is an analog of PGE 1 II Is used to prevent gastric ulcers in patients III Is an analog of PGF 1 α a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 5. The drug illustrated below: F CH 2 CO 2 H CH 3 C H S H 3 C O I Is a pro-drug that must be metabolized to a sulfone to become active as an antiinflammatory agent II Inhibits cyclooxygenases after being metabolized to its active form III Is a pro-drug that must be metabolized to a sulfide to become active as an antiinflammatory agent a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 6. The drug illustrated below: O H 3 CO H 3 CO H 3 CO OCH 3 NH H C O CH 3 I Is used to treat chronic gout II Is a uricosuric agent III Inhibits the migration of granulocytes into the area of inflammation during an acute gout attack a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer
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3 7. The drug illustrated below: N CO 2 CH 3 H CH 3 O O H I Is highly psychologically-addicting II Is a benzoate ester local anesthetic III Is completely uncharged at pH 7.4 a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 8. The drug illustrated below: O CH 3 O N CH 3 OH O H Cl H I Has little or no antitussive activity II Is orally active III Is used to treat pain a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 9. The drug illustrated below: N CH 3 H H H CH 3 O Br I Is a µ -agonist II
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mcII05e2 - MEDICINAL CHEMISTRY II EXAM #2 April 1, 2005...

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