mcI08e1 - MEDICINAL CHEMISTRY I EXAM#1 October 3 2008 Name...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
MEDICINAL CHEMISTRY I EXAM #1 October 3, 2008 N a m e SECTION A. Answer each question in this section by writing the letter corresponding to the best answer on the line provided (2 points each; 30 points total) 1. The compound shown below: I Is an acid with K a = 1 x 10 -7 II Contains a sulfonamide group III Is an acid with a pK a = 7 a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 2. The compound shown below: I Is a cyclic carbamate II Contains an amine functional group III Contains a lactone functional group a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 3. For the compounds illustrated below: I Compound A has a larger pK a than compound B II Compound B is a stronger acid than compound A III The conjugate base of compound B is a weaker base than the conjugate base of compound A a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 1
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
2 4. The compound illustrated below: N O O CH 3 I Is a cyclic imide II Behaves as an acid in aqueous solution III Is a cyclic urea a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 5. For the compounds illustrated below: NH NH 2 AB I Compound A has a pK b = 10 II Compound B is a tautomer of compound A III Compound B has a pK b = 10 a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 6. The compound shown below: I Has ( S )-stereochemistry at position 1, ( Z) -geometry at double bond A and ( Z )-geometry at double bond B II Does not have a chiral center III Has ( R )-stereochemistry at position 1, ( Z) -geometry at double bond A and ( E )-geometry at double bond B a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 7. In the compound illustrated below: O 1 2 4 5 6 3 I Carbon-6 and carbon-2 are in the same plane II The hybridization of the oxygen is sp 2 III Carbon-4 and carbon-1 are in the same plane a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer
Background image of page 2
3 8. For the structures illustrated below: I When X = CH 3 compound B is a stronger base than compound A II When X = NO 2 compound B is a weaker base than compound A III When X = OCH 3 the conjugate acid of compound B is a weaker acid than the conjugate acid of compound A a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 9. For the structures illustrated below: N CH 3 CH 3 CH 3 N CH 3 H 3 C CH 3 AB I Structure A is an acid and structure B is its conjugate base II Structure B has a larger log P than structure A III Structure A is 100% ionized at pH = 7 a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 10. In the compound illustrated below: I There are only two aromatic rings II There is one basic and one neutral nitrogen III There are three aromatic rings a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 11. The compound illustrated below: I Is 1,2,4-triazine II Has pK b = 10 at the nitrogen with the arrow III
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

Page1 / 13

mcI08e1 - MEDICINAL CHEMISTRY I EXAM#1 October 3 2008 Name...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online