McI08e1 - MEDICINAL CHEMISTRY I EXAM#1 October 3 2008 Name SECTION A Answer each question in this section by writing the letter corresponding to

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
MEDICINAL CHEMISTRY I EXAM #1 October 3, 2008 N a m e SECTION A. Answer each question in this section by writing the letter corresponding to the best answer on the line provided (2 points each; 30 points total) 1. The compound shown below: I Is an acid with K a = 1 x 10 -7 II Contains a sulfonamide group III Is an acid with a pK a = 7 a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 2. The compound shown below: I Is a cyclic carbamate II Contains an amine functional group III Contains a lactone functional group a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 3. For the compounds illustrated below: I Compound A has a larger pK a than compound B II Compound B is a stronger acid than compound A III The conjugate base of compound B is a weaker base than the conjugate base of compound A a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 1
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 4. The compound illustrated below: N O O CH 3 I Is a cyclic imide II Behaves as an acid in aqueous solution III Is a cyclic urea a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 5. For the compounds illustrated below: NH NH 2 AB I Compound A has a pK b = 10 II Compound B is a tautomer of compound A III Compound B has a pK b = 10 a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 6. The compound shown below: I Has ( S )-stereochemistry at position 1, ( Z) -geometry at double bond A and ( Z )-geometry at double bond B II Does not have a chiral center III Has ( R )-stereochemistry at position 1, ( Z) -geometry at double bond A and ( E )-geometry at double bond B a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 7. In the compound illustrated below: O 1 2 4 5 6 3 I Carbon-6 and carbon-2 are in the same plane II The hybridization of the oxygen is sp 2 III Carbon-4 and carbon-1 are in the same plane a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer
Background image of page 2
3 8. For the structures illustrated below: I When X = CH 3 compound B is a stronger base than compound A II When X = NO 2 compound B is a weaker base than compound A III When X = OCH 3 the conjugate acid of compound B is a weaker acid than the conjugate acid of compound A a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 9. For the structures illustrated below: N CH 3 CH 3 CH 3 N CH 3 H 3 C CH 3 AB I Structure A is an acid and structure B is its conjugate base II Structure B has a larger log P than structure A III Structure A is 100% ionized at pH = 7 a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 10. In the compound illustrated below: I There are only two aromatic rings II There is one basic and one neutral nitrogen III There are three aromatic rings a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 11. The compound illustrated below: I Is 1,2,4-triazine II Has pK b = 10 at the nitrogen with the arrow III
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 04/14/2009 for the course 663 701 taught by Professor Arnold,e. during the Spring '09 term at Rutgers.

Page1 / 13

McI08e1 - MEDICINAL CHEMISTRY I EXAM#1 October 3 2008 Name SECTION A Answer each question in this section by writing the letter corresponding to

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online