mcI07e3 - 1 Medicinal Chemistry I Examination December 7...

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1 Medicinal Chemistry I Examination December 7, 2007 Name Med. Chem. # THERE ARE TWELVE PAGES IN THIS EXAM ! Part I. 60 Points (30 Questions; 2 Points Each) Select the BEST answer for each of the following. 1. The drug illustrated below: N S CH 2 CH N CH 3 H 3 C H 3 C I Has antiemetic activity. II Is active as a H 1 antagonist. III Causes sedation. a I only b III only c I and II only d II and III only e I, II, and III Answer 2. The drug illustrated below is: N CH 2 CH 2 CH 2 HC OH CH 2 N CH 2 CH 2 N N n I Is an enzyme inhibitor. II Can be administered iv. III Binds bile acids and prevents their reabsorption. a I only b III only c I and II only d II and III only e I, II, and III Answer 3. The drug illustrated below is : OCH 3 OCH 3 C CH 2 CN (H 3 C) 2 HC CH 2 H 2 C N CH 3 CH 2 CH 2 OCH 3 OCH 3 I Used to treat angina. II Used to treat arrhythmias. III Known to increase serum triglycerides. a I only b III only c I and II only d II and III only e I, II, and III Answer
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2 4. The drug illustrated below: I Is an α 2 -agonist (centrally-acting). II Physically displaces norepinephrine from storage granules. III Blocks the refilling of norepinephrine in storage granules. a I only b III only c I and II only d II and III only e I, II, and III Answer 5. The drug illustrated below: N NH S O O CH 3 Cl I . Is a thiazide diuretic. II Is used iv to reduce blood pressure. III Is used orally to treat insulin-induced hypoglycemia. a I only b III only c I and II only d II and III only e I, II, and III Answer 6. The drug illustrated below is: N N N H 3 CO H 3 CO NH 2 N C O O I Is used as an antihypertensive agent. II Is associated with lower serum LDL. III Is associated with orthostatic hypotension as a side effect. a I only b III only c I and II only d II and III only e I, II, and III Answer 7. The drug illustrated below: O O C CH 3 CH 3 C O O CH H 3 C H 3 C Cl I Is a prodrug. II Increases Lipoprotein Lipase activity in endothelial cells. III A Class IB antiarrhythmic agent. a. I only b. III only c. 1 and II only d. II and III only e. I, II, and III Answer
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3 8. The drug illustrated below: CH 2 CH 2 C H C N H OH O C H CH 2 CH 2 CH 2 CH 2 NH 2 C O N H C HO O I Acts as a receptor antagonist. II Can produce a non-productive dry cough. III Is an angiotensin-converting enzyme inhibitor. a I only b III only c I and II only d II and III only e I, II, and III Answer 9. The drug illustrated below: N NH S O O H N O HN CH(CH 3 ) 2 CH 3 I Can cause hyperkalemia. II Can cause hypomagnesemia. III
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mcI07e3 - 1 Medicinal Chemistry I Examination December 7...

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