mcI07e2 - 1 Medicinal Chemistry 409 Name Med. Chem. #...

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1 Medicinal Chemistry 409 Name Med. Chem. # November 2, 2007 THERE ARE TWELVE PAGES IN THIS EXAM Select the best answer for each of the following (60 Points, 2 Points each): 1. The drug illustrated below is: N S H 2 CH 2 C O OCCH 3 H H O N H 3 C H 3 C OCH 3 I A calcium channel blocker. II Can be used as an antiarrhythmic agent. III Can be used to treat angina. a I only b III only c I and II only d II and III only e I, II, and III Answer 2. The drug illustrated below: I Can cross the blood brain barrier. II Is used as an adjunct in the treatment of Parkinson’s disease. III Can cause miosis. a. I only b. III only c. I and II only d. II and III only e. I, II, and III Answer 3. The drug illustrated below is: H 3 C CH 3 C CH 3 H 3 C CH 3 CH 2 N HN I An 1 -antagonist. II A potent peripheral vasodilator. III Used as a nasal decongestant. a I only b III only c I and II only d II and III only e I, II, and III Answer
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2 4. The drug illustrated below: C OH H CH NH H OCH 3 H 3 CO O CH 2 NH 2 I Is used to treat othostatic hypotension. II Is a prodrug that is activated to an α 1 -agonist. III Is a potent dopa decarboxylase inhibitor. a I only b III only c I and II only d II and III only e I, II, and III Answer 5. The drug illustrated below is: I An anticholinergic agent. II Used post-operatively to stimulate the GI tract. III Primarily a direct-acting cholinergic agent. a I only b III only c I and II only d II and III only e I, II, and III Answer 6. The drug illustrated below is: I Frequently associated with liver toxicity. II An indirect-acting cholinergic agonist. III Used to treat Alzheimer’s disease. a. I only b. III only c. I and II only d. II and III only e. I, II, and III Answer 7. The drug illustrated below: I . Can decrease heart rate. II Is used to treat hypertension. III Is a non-selective β-blocker. a I only b III only c I and II only d II and III only e I, II, and III Answer CHCH 2 N CH 3 CH 3 CH 3 O C NH 2 O CH 3 Cl
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3 8. The drug illustrated below: OH O O N CH 3 CH 3 Br I Is used as a GI antispasmodic. II Can cause miosis. III Is a cholinergic agonist. a I only b III only c I and II only d II and III only e I, II, and III Answer 9. The drug illustrated below: I Is a selective monoamine oxidase inhibitor (MAO-B). II Frequently causes sleeplessness (insomnia). III Cannot cross the Blood Brain Barrier. a I only b III only c I and II only d II and III only e I, II, and III Answer 10. The drug illustrated below is: I Used to prevent exercise-induced bronchospasm (EIB) II Prescribed for the treatment of hypertension. III
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mcI07e2 - 1 Medicinal Chemistry 409 Name Med. Chem. #...

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