mcI06e3 - 1 Medicinal Chemistry I Examination Name December...

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1 Medicinal Chemistry I Examination N a m e December 1, 2006 Med. Chem. # THERE ARE THIRTEEN PAGES IN THIS EXAM ! Part I. 66 Points (33 Questions; 2 Points Each) Select the BEST answer for each of the following . 1. The drug illustrated below: CH 2 CH 2 C H C N H OH O C H CH 2 CH 2 CH 2 CH 2 NH 2 C O N H C HO O I Is used to treat hypertension. II Can cause a dry non-productive cough. III Is used to treat congestive heart failure. a I only b III only c I and II only d II and III only e I, II, and III Answer 2. The mixture of drugs illustrated below: CH 3 CHCH 2 CH 2 CH 3 ONO CH 3 CH 2 CHCH 2 CH 3 + I Increases levels of cGMP in vascular smooth muscle. II Can be used to treat angina. III Is administered orally. a I only b III only c I and II only d II and III only e I, II, and III Answer 3. The drug illustrated below: N N N N S O O N N H 3 C O CH 3 O CH 2 CH 3 CH 2 CH 2 CH 3 H I Is a phosphodiesterase inhibitor-type 5. II Is used to treat pulmonary hypertension. III Is a receptor antagonist. a I only b III only c I and II only d II and III only e I, II, and III Answer
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2 4. The drug illustrated below: O O N H NH 2 NH I Prevents the entry (refilling) of norepinephrine into storage granules. II Is administered initially at a high bolus dose with subsequent lower maintenance doses. III Displaces norepinephrine from storage granules. a I only b III only c I and II only d II and III only e I, II, and III Answer 5. The drug illustrated below: N H 3 C H CH 3 C O OCH 2 CH 2 N H H 3 CO O NO 2 CH 3 CH 2 I Is a calcium channel blocker. II Is available as an iv formulation. III Could cause reflex tachycardia. a I only b III only c I and II only d II and III only e I, II, and III Answer 6. The drug illustrated below: N N N N N N H H 2 C C O O HC CH 3 O C O O O CH 2 CH 3 I Is used to treat hypertension. II Is a cascading prodrug. III Frequently causes a dry non-productive cough. a I only b III only c I and II only d II and III only e I, II, and III Answer 7. The drug illustrated below: S N CH 2 CH CH 3 N H 3 C H 3 C I Is a H 1 -receptor antagonist. II Can cause sedation. III Has significant anticholinergic activity and antiemetic properties. a I only b III only c I and II only d II and III only e I, II, and III Answer
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3 8. The drug illustrated below is: N NH S OO CH 3 Cl I Can be used iv to treat hypertension. II Can be used orally to treat hyperinsulinism III A thiazide diuretic a I only b III only c I and II only d II and III only e I, II, and III Answer 9. The drug illustrated below: I Can effectively reduce HDL cholesterol levels. II Is a bile acid sequesterant. III Is safe to use during pregnancy. CH 2 2 2 N(C H 3 ) 3 2 2 ... ... a I only b III only c I and II only d II and III only e I, II, and III Answer 10. The drug illustrated below: N N N H 3 CO H 3 CO NH 2 N C O O O I Is used as an antihypertensive agent.
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This note was uploaded on 04/14/2009 for the course 663 701 taught by Professor Arnold,e. during the Spring '09 term at Rutgers.

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mcI06e3 - 1 Medicinal Chemistry I Examination Name December...

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