mcI05e3 - Medicinal Chemistry I Examination Name December...

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Medicinal Chemistry I Examination N a m e December 2, 2005 Med. Chem. # Part I. (66 Points 33 Questions 2 Points Each): Select the BEST answer for each of the following . 1. The drug illustrated below: N N N N S O O N N H 3 C O CH 3 O CH 2 CH 3 CH 2 CH 2 CH 3 H I Is an opthalmic used to treat allergic conjunctivitis. II Inhibits the release of histamine from mast cells. III Is a phosphodiesterase inhibitor-type 5. a I only b III only c I and II only d II and III only e I, II, and III Answer 2. The drug illustrated below: CH 2 CH 2 C C OC 2 H 5 O H N C H H 3 C H C N O H H C H O OH I Is a receptor antagonist. II Is a prodrug. III Is an enzyme inhibitor. a I only b III only c I and II only d II and III only e I, II, and III Answer 3. The drug illustrated below: O O H H ONO 2 O 2 NO I Increases levels of cGMP in vascular smooth muscle. II Is used to treat angina. III Combines with calmodulin to form a complex. a I only b III only c I and II only d II and III only e I, II, and III Answer
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4. The drug illustrated below: O O N H NH 2 NH I Displaces norepinephrine from storage granules. II Prevents the entry (refilling) of norepinephrine into storage granules. III Is an α 2 -agonist (central). a I only b III only c I and II only d II and III only e I, II, and III Answer 5. The drug illustrated below: N N S N O O CH 2 CHOH CH 2 NHC(CH 3 ) 3 I Is used to treat hypertension. II Is used to treat chronic open-angle glaucoma. III Is a β 1 and β 2 adrenergic agonist. a I only b III only c I and II only d II and III only e I, II, and III Answer 6. The drug illustrated below: S N CH 2 CH CH 3 N H 3 C CH 3 I Can cause sedation. II Has antiemetic activity. III Is a H 1 -receptor antagonist. a I only b III only c I and II only d II and III only e I, II, and III Answer 7. The drug illustrated below is: Cl Cl S S O O H 2 N O O NH 2 I Is used to treat hypertension. II Is an α 2 agonist (central). III Is used to treat glaucoma a I only b III only c I and II only d II and III only e I, II, and III Answer
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8. The drug illustrated below: N CH 3 HN O Cl S NH 2 O O I . Is a phosphodiesterase inhibitor. II Can cause hypokalemia. III Is a thiazide diuretic. a I only b III only c I and II only d II and III only e I, II, and III Answer 9. The drug illustrated below: I Is a bile acid sequesterant. II Is safe to use during pregnancy. III Can reduce HDL cholesterol levels. CH 2 2 2 N(C H 3 ) 3 2 2 ... ... a I only b III only c I and II only d II and III only e I, II, and III Answer 10. The drug illustrated below: N N N H 3 CO H 3 CO NH 2 N C O O O I Is used as an antihypertensive agent. II Is used for symptomatic relief in individuals with benign prostatic hyperplasia.
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mcI05e3 - Medicinal Chemistry I Examination Name December...

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