mcI05e2 - 1 Name Medicinal Chemistry 409 October 28, 2005...

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1 Medicinal Chemistry 409 N a m e October 28, 2005 Med Chem # THERE ARE TWELVE PAGES IN THIS EXAM Part 1 Select the Best and Most Complete answer for each of the following (54 Points: 2 points EACH): 1. The drug illustrated below: H CH 3 H H H H H H 3 CCO N CH 3 O Br H 3 C OCCH 3 N H H CH 3 O Br I Is a depolarizing neuromuscular blocking agent. II Could be used to treat myasthenia gravis. III Is a non-depolarizing neuromuscular blocking agent. a. I only b. III only c. I and II only d. II and III only e. I, II, and III Answer 2. The drug illustrated below: N O OH H H CH 3 H 3 CO I Can be used to treat Alzheimer’s disease II Is an indirect-acting cholinergic agonist III Inhibits the function of an enzyme. a. I only b. III only c. I and II only d. II and III only e. I, II, and III Answer 3. The drug illustrated below: O H 2 C CHOH CH 2 NHCH(CH 3 ) 2 CH 2 OCH 2 CH 2 OCH(CH 3 ) 2 I Is a non-selective β -antagonist with ISA. II Is used to treat hypertension. III Is a β 1 -selective antagonist. a. I only b. III only c. I and II only d. II and III only e. I, II, and III Answer
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2 4. The drug illustrated below: H 3 CC 3 CCH 3 H 3 C CH 3 CH 2 N HN H I Is an α -antagonist. II Is an α 1 -agonist. III Is used as a nasal decongestant. a. I only b. III only c. I and II only d. II and III only e. I, II, and III Answer 5. The drug illustrated below: CH 2 ONO 2 CH 2 ONO 2 CH O 2 NO I Is used to treat angina. II Is a vasodilator. III Can cause reflex tachycardia. a. I only b. III only c. I and II only d. II and III only e. I, II, and III Answer 6. The drug illustrated below: O O N N CH 3 H 3 C H 3 C CH 3 CH 3 H 3 C Br Br O O I Is a depolarizing neuromuscular blocking agent. II Has a short duration of action. III Is a prodrug. a. I only b. III only c. I and II only d. II and III only e. I, II, and III Answer 7. The drug illustrated below: N N CH 3 CH 3 H H O C O N H H 3 C I Inhibits acetylcholinesterase. II Produces mydriasis. III Blocks cholinergic receptors a. I only b. III only c. I and II only d. II and III only e. I, II, and III Answer
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3 8. The drug illustrated below: C OH H C NHCH 3 H CH 3 I Acts exclusively as a norepinephrine releaser. II Is used an adjunct in the treatment of Parkinsonism. III Is a direct adrenergic agonist and a norepinephrine releaser. a. I only b. III only c. I and II only d. II and III only e. I, II, and III Answer 9. The compound illustrated below is: P O OCH 2 CH 3 OCH 2 CH 3 HCHCH 2 S N H 3 C H 3 C CH 3 I I An Indirect cholinergic agonist.
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mcI05e2 - 1 Name Medicinal Chemistry 409 October 28, 2005...

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