mcI05e1 - 1 MEDICINAL CHEMISTRY I EXAM#1 Name SECTION A...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
1 MEDICINAL CHEMISTRY I EXAM #1 September 30, 2005 N a m e SECTION A. Answer each question in this section by writing the letter corresponding to the best answer on the line provided (2 points each; 50 points total) 1. The compound shown below: N H N I Is a base with a pK b value of 10 II Is 2-Imidazoline III Is a base with a pK b value of 3 a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 2. The functional group in the compound illustrated below: O H N O I Is a carbamate II Is an acid with a pK a value of 12 III Is a carbonate a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 3. For the structures illustrated below: OH S H 3 C O OH S H 3 C A B I Compound A is a stronger acid than compound B II Compound B has a larger log P value than compound A III Compound B has an electron-donating substituent para to the hydroxy group a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 4. The drug illustrated below: O HO N H 2 C CH OH O CH 2 I Has a benzyl group attached to the nitrogen II Contains a lactone functional group III Has a conjugate acid form with a pK a value of 9 a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 5. The compound illustrated below: N H Br I Has a conjugate base form with a pK b value of 10 II Is 50% ionized at pH 4 III Is 100% ionized at all pH values a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 6. For the compound shown below: CC C Cl Cl H 3 C H 3 C I The hybridization of the carbon with the two chlorines is sp 2 II The chlorines are in a plane that is perpendicular to that of the methyl groups III The hybridization of the carbon with the two methyl groups is sp 2 a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer
Background image of page 2
3 7. For the compounds illustrated below: CH 3 OH Cl H H CH 3 Cl HO A B I Structures A and B represent the same compound II Structures A and B are enantiomers III Structure B has the R-configuration a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 8. The drug illustrated below: NH H N O O I Is 5,5-diphenylimidazolidine-2,4-dione II Contains a group that is an acid with a pK a value of 9 III Has the pro-S phenyl group oriented behind the paper a) I only b) III only c) I and II only d) II and III only e) I, II, and III Answer 9. The compound illustrated below: O O I Contains a cyclic ether II Is 2H-tetrahydrooxecin-2-one III Is tetrahydrooxonin-2-one a) I only b) III only c) I and II only
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 04/14/2009 for the course 663 701 taught by Professor Arnold,e. during the Spring '09 term at Rutgers.

Page1 / 11

mcI05e1 - 1 MEDICINAL CHEMISTRY I EXAM#1 Name SECTION A...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online