mcI04e2 - 1 Medicinal Chemistry I Examination October 31st,...

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1 Medicinal Chemistry I Examination October 31 st , 2004 N a m e Med. Chem. # Student # THERE ARE TWELVE PAGES IN THIS EXAM! Part I (50 Points). Select the Best and Most Complete Answer for each of the following : 1. The drug illustrated below is: N CH 3 CH 3 O O N H 3 C CH 2 CH 3 CH 3 H I Used to treat Alzheimer’s disease. II An indirect-acting cholinergic agonist. III Interacts with an enzyme. a. I only b. III only c. I and II only d. II and III only e. I, II, and III Answer 2. The drug illustrated below: N CH 3 H 3 CO O H H 3 CO O N OCH 3 H 3 C CH 3 H I OCH 3 H 3 C I I Is a depolarizing neuromuscular blocking agent. II Is used to treat Parkinsonism. III Is a non-depolarizing neuromuscular blocking agent. a I only b III only c I and II only d II and III only e I, II, and III Answer 3. The drug illustrated below is: NH NH N Cl Cl I Is used to treat hypertension. II Inhibits the release of norepinephrine. III Is an α 2 -agonist that acts centrally. a I only b III only c I and II only d II and III only e I, II, and III Answer
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2 4. The drug illustrated below: O H 2 C CHOH CH 2 NHCH(CH 3 ) 2 CH 2 CH 2 OCH 3 I Is a non-selective β -antagonist. II Is used to treat hypertension. III Is a β 1 -selective antagonist. a I only b III only c I and II only d II and III only e I, II, and III Answer 5. The drug illustrated below: H 3 CC 3 OH CCH 3 H 3 C CH 3 CH 2 N HN H I Is an α -antagonist. II Is an α 1 -agonist. III Is used as a nasal decongestant. a I only b III only c I and II only d II and III only e I, II, and III Answer D 6. The drug illustrated below: O O N N CH 3 H 3 C H 3 C CH 3 CH 3 H 3 C Br Br O O I Is a depolarizing neuromuscular blocking agent. II Acts by inhibiting acetylcholinesterase. III Is used to treat Alzheimer’s disease. a I only b III only c I and II only d II and III only e I, II, and III Answer 7. The drug illustrated below: O CH 3 H 3 C CH 3 N CO N H 3 C CH 3 Br I Inhibits acetylcholinesterase II Can produce miosis III Blocks cholinergic receptors a I only b III only c I and II only d II and III only e I, II, and III Answer
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3 8. The drug illustrated below: N CH 3 OC O CH CH 2 OH H I Blocks post-ganglionic parasympathetic receptors. II Can increase heart rate. III Does have CNS effects. a I only b III only c I and II only d II and III only e I, II, and III Answer 9. The drug illustrated below: CH HO CN H C H 3 H CH 3 I Is only a norepinephrine releaser.
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This note was uploaded on 04/14/2009 for the course 663 701 taught by Professor Arnold,e. during the Spring '09 term at Rutgers.

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mcI04e2 - 1 Medicinal Chemistry I Examination October 31st,...

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