aspirin analysis formal lab report

aspirin analysis formal lab report - Kristina Madore March...

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Kristina Madore March 5, 2008 Title: The Synthesis, Purification, and Colorimetric Analysis of Aspirin Introduction: The purpose of this experiment was to synthesize a common, over-the-counter drug that is used daily by many people around the world as a pain killer, fever reducer, and blood thinning agent. During the lab aspirin was synthesized, purified, and analyzed. The aspirin was synthesized by combining salicylic acid and acetic anhydride. The product was then crystallized to form a very impure aspirin. To purify the product, it was boiled down and recrystallized. Analysis of this purified aspirin was completed in a couple of steps. The first step was to measure the absorption spectrum of the aspirin complex to determine the maximum wavelength. Second, a Beer’s Law plot, Figure 1, was created to demonstrate the relationship between the maximum absorbance and the concentration of the aspirin. Finally, the absorbance of the aspirin was measured at the maximum wavelength determined in the first step. All of these procedures led to the determination of how pure the synthesized aspirin really was. Experimental: For the first part of the procedure, an aspirin complex was synthesized. Salicylic acid (3.010 grams) was weighed out and placed into a 125 mL Erlenmeyer flask. Acetic anhydride (6 mL) and five drops of concentrated sulfuric acid were added to the salicylic acid in the flask. The reactants were mixed thoroughly by swirling the flask. The flask was placed in an 80-90°C water bath for around twenty minutes. After the elapsed time, it was removed from the hot water bath and allowed to cool to room temperature. Distilled water (40 mL) was added to the mixture in the flask. It was placed into an ice bath to crystallize. A Büchner funnel was used to separate the 1
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solid from the liquid. This procedure was completed multiple times to ensure that all of the solid was taken out of the solute. The solid was rinsed with ice-cold distilled water and dried by pressing it between two pieces of filter paper. When fully dried, the crude aspirin was weighed at about 2.68 grams. To purify the synthesized, crude aspirin, the recrystallization method was used. The aspirin was dissolved in a 125 mL Erlenmeyer flask with ethanol. The amount of ethanol (8.04mL) was proportional to the amount of synthesized aspirin, as shown in equation 1. For every synthesized gram of aspirin, 3 mL of ethanol was used. The flask was placed into a 70°C hot water bath until all of the solid aspirin complex had dissolved. Distilled water (50 mL) was added to the dissolved solution. The solution was then cooled slowly with a watch glass over the top. After ten minutes of letting it cool to room temperature, it was then placed in an ice bath until recrystallization occurred. The solid was separated by passing it through a Büchner funnel and allowed to dry on a piece of filter paper for a week. The final mass of the aspirin was .5895 grams. The theoretical yield of aspiring was calculated using Equation 2 and percent yield of the
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This note was uploaded on 04/29/2008 for the course CHEM 221 taught by Professor Fillinger during the Spring '08 term at Ithaca College.

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aspirin analysis formal lab report - Kristina Madore March...

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