Fertiliztion- AS 320 pp - FERTILIZATION: fusion of two...

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FERTILIZATION: fusion of two cells, ovum and sperm, to form one cell zygote. 1) Capacitated, hyperactivated sperm attaches to the zona pellucida a) species specific, receptor: ZP3, carbohydrate receptor on ZP3 b) sperm-ZP3 binding triggers acrosome reaction c) Sperm releases from receptor and proteases, glycosidases and hyperactivity involve with penetration of ZP - “zona lysin” is a term sometime used to describe unidentified enzymes that help digest a pathway, no bigger than sperm head, through the zona
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Acrosome Reaction Fusion of inner and outer acrosomal membranes Vesiculation Timely release of acrosin and other enzymes Flagellar action Equatorial segment http://biology.plosjournals.org/archive/1545-7885/3/10/ www.ejpau.media.pl/volume8/issue4/art-54-fig3.jpg
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2) Sperm passes through zona pellucida into perivitelline space and equatorial region of sperm head fuses with membrane of ovum - not species specific: example: “hamster penetration test” -only acrosome reactivated sperm bind -may involve ADAM (A Disintegrin And Metalloprotease) family proteins on sperm, specifically fertilin and cyritestin binding to egg integrin alpha 6 B1 but mouse knockout models do not support this, recent evidence suggests egg CD9 involved. -microvilli on egg membrane engulf sperm
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This note was uploaded on 04/29/2008 for the course ANIMAL SCI 320 taught by Professor Godkin during the Spring '08 term at University of Tennessee.

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Fertiliztion- AS 320 pp - FERTILIZATION: fusion of two...

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