Sample exam midterm _3

Sample exam midterm _3 - GrsthMmmLQflhfllm—F— WMEM;...

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Unformatted text preview: GrsthMmmLQflhfllm—F— WMEM; émrkm Muhiplo choice questions l-Efl, 4 points each. Place the capital letter concsponding to thc corrch month fincatthc loft ofcachquosfion. I. Which is a correct name for CHEC HINHCHCHZCHsz . éH3 A} N—ethad-Z-pcntanamuw H) mmme C] Hmyl—N-mmyl-l-humm 13'} all?! how E) cthyhrflhyfisohnylmnmc IWchisacorroctlmmcfiof if, Cl A} 3-chloropyfimidinc m. l B) 3.me N C) 3-ch1oropipcfidine D} 3-ch1orop3rrmle E] 3-chloropy1'idim 3. For compounds D-R, which is rmst acidic? 4. For compounds fl-R, which is least acidic? #h ‘i‘ H H HH o P Q 5. For compounds L, M, N, what isthc most acidic? M 1!: r~|I+ LH ti. What Ethic major product in the rcsction of furnn with flagrant-Br3 ‘? Br Br J ._._. lilr “ A B C D E 7. WI is the major product in the following elimination rcnction'? OH- CH H {CHsl3N+ {:H:i 3‘ ((3%?ij C 3 (CI-imbibe]: —-I- é\{SHg CH3 CH3 H3 CH3 CH3 5 I] C I} E 3. lnfidszolc has a pKn for its conjugate acid [imidszoliorn ion} of 15.3. Thc pKa for itnitlazolc itselfis 14.4. m a pH of 1111.6. which of the following statcmcrrts is truc‘? A} The major form present is thc ion. B} The ijor form present is infidamle itself. C} The major form present is the irnidazolc anion. D] The imidnzolitnnionandhfldazolcarcprcscntin a H ratio. E)Thci1nidarolcsnionnod imidszolcsrc presentinn 1:1 ratio. 9. Which of thc sugars below hnvc the (5}configoration at each chiral corner? H .3 H o H o H o H cm H on H H Ho H H on H H H H H H 111on HECIH Hon ngoH A n c o it]. Which ofthc following statcmcnts is n_ot true about [ll—glucose? A} ELglucose is a hoxosc. B} [ll-glucose is an aldose. C} D-glucosc is a ketosc. D} D~glucosc is mainly in pyranosc form in solution. E] Drglucosc is a reducing sugar. 11. Which ofthc following state-mm is mu: about D‘flthflSfl and D—manmsc‘? A] III-Glucose and D-mmmae are ennntinmers. B} D-Ghmom and D-mmmsa are epinwm C] D—Giuwae and D—maxmose are amma D) D—GIH'DDEE and D—manmae are alditnls. E} D—Ghlmsa and 111-me033 451} mt farm the same Elmira. 12. How many Open-chain stereoisnnrrs are 11055in for a kflol‘mxase? A} 2 E] 4 C} {i D} E E} 1-6 13. Which is the GDII‘BIH Hawrth projth uffl-D—galacmsc? CHIQH CHIOH H 0 H a mil-3H B C ‘5’” H OH OH OH H H H H H H H UH H H H H 10H CHIDH Han OH 0 “M ' DH 0 HH D H H E H H 14. A Hawflrth projection ann: ufflwe a}!ch fauna nfD—altrose is Show heinw. Which is the correct chair confirmation“? CHon CH DH 0 OH H 1 0 H0 CHZOH “ H0 B H OH OH OH '3 H0 0 Dwahme HG CHan EHzDH Wzgfl c 0“ H D U 11 H0 H0 E DH 0 1-10 UH UH _ 15. At pH T, which repmus the predunfinmn fiarm ufarginine in solution? (pKa values for mime are 12.43, 9.04, 2.11}? 5) 1% «- HQNCNHCH-zCHICHgllli-Kgfl‘ Hg‘NCNHCHEC HIEH1?HI:0' A +‘HH3 3 *NHg 3:” {a 1.3m '9: H2NCNHCH28H1CEfi$HILSD' HgNCNHCHzC Hzcnlclean C W H3, I. +NH3 +NH1 IR IEIHgNl-ICEHC}I1CH1$EEOH E *NH3 16. What isthe pl with: for arng (see pmhlem 15 Ear pKa data}? A} WJfi B) ELEM {I} 7.911] D} 132 E} 5.65} 1?. Which thhE fuliuwing almuld have the [Omar pl valut? ‘3' ‘fi' E? *5! I! _ - HSC H1{IIHC 0" CH3?HCO- DC CHflEH‘CU A +NH3 n +NH3 C "'hl H3 emit ahn'm napalm: U D u u _ [3—420- {iTHECfl Nx *NH 9 H’ H E 3' pm“ slams 13. Wide}: ammo acid below wmdd he chum! firm. at pH 4.4, {him an ion exchange culumn packad with a cumin-exchange resin such as Dom 511? (see probIEms 15 and 1? for structures} A]: arginine H} mm C} prelim: D] W E} cysteine 19'. Which anfim acid i5 irWDt'I-Pcd in fflmfing covalent hands betmn floundij amino acids in peptidacs and premium? A) arginine B} 3113111113 (1} pruline D}as;1artate E) cysteine 2|}. Which ef the 5 hemapeptides A‘E heiew eeuhi he the primaryr structure Ufa heptapeptide for which the feflnwhig ebeen'atiena were made: i} Cnmptete hydmlysie showed 2 Tyr, 2 Gly, Len, Set, and His ii) Edna‘s reagent releaeed Leu iii) A carhuxypeptidase released T31 iv} in additien tn imiividual fllflim acids, partial hydrehraie game thee peptide fiagrnmts with the sequences; Ty'r‘Serth-r. Cub-Ty, and Gh'wHiS A] Leu-Gly-hrr-Sen-Hissfilyh'l‘yr a} Hr—SernGIy—Tyr—Glyfii-fisaleu C) TyT-Ser-Gly—Leu-Ghr-Pfis-Tyr D} LeIJvGIy-Hi S‘Tfl‘SEPGi‘f-TYI E] Len-Ty‘r-Ser—Glf—Gh—Hiaflyr 21 . (6 points] Are there an}:r ether heptapeptidee which would satiafj.r the itrf'ennatien given in problem 2i}? Ifae, what are they? 22. {12 points) Whai pyrmside products are fermd when D—aitmse {see question 14} reacts with ene equivalent nfmetimlnl in the presence efHCI'? Write a mechanism for this reaction. 3-3- 6ifijNeutm! imidmle is both a stronger base and a stronger acid than ply-1101:. Explain this martyr, imlmling appropriate remname structmes in your explaimiun. imitiaznle th H ...
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This note was uploaded on 04/30/2008 for the course CHM 313 taught by Professor Forsyth during the Spring '08 term at Northeastern.

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Sample exam midterm _3 - GrsthMmmLQflhfllm—F— WMEM;...

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