Homeobox Gene - Amber Tincher Anatomy 518 February 13 th ,...

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Unformatted text preview: Amber Tincher Anatomy 518 February 13 th , 2008 Objective: Define and describe homeobox gene with special reference to Hox. Some Terminology Homeo in Greek means similar Homeotic mutants are mutants in which one structure is replaced by another (antenna for a leg) Homeotic genes are genes whose mutation can cause transformations, and therefore they specify the identity of a particular body segment Homeobox Definition of Homeobox: Homeobox genes are genes found in eukaryotes which play a major part in regulating development. All vertebrates carry groups of highly conserved genes homeobox genes that share a region of homology These regulatory genes encode nuclear proteins that act as transcription factors to control the expression of other developmentally important genes Homeobox genes encode transcription factors A single homeobox gene can cause a cascade of other genes to be turned on, producing an entire body segment of limb. Homeobox genes contain a stretch of DNA approximately 180 base pairs (60 amino acids) long called a homeobox which encodes a protein domain, called a homeodomain capable of binding to DNA. Single homeodomains are not usually specific enough to target the exact genes they are to turn on, so homeodomains usually work on complexes with other proteins. Homeobox Each gene encodes a protein that includes the 60 amino-acid homeodomain this part of protein bonds to DNA, regulating transcription of important genes Homeotic genes are located close together, in same order as the body segments, whose development they control Nearly identical gene sequences were found in mice Mouse genes were names Hox genes for homeoboxes they contain...
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This note was uploaded on 04/30/2008 for the course EMBRY 518 taught by Professor Many during the Spring '08 term at North Dakota.

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Homeobox Gene - Amber Tincher Anatomy 518 February 13 th ,...

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