Formation of the AER and Limb Bud

Formation of the AER and Limb Bud - Formation of the AER...

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Formation of the AER and  Limb Bud Amber Tincher Anatomy 518, Case 10 April 2 , 2008
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Limb Buds Limb buds appear as  elevations of the  ventrolateral body wall late  in 4 th  week Begins with activation of a  group of mesenchymal cells  in the lateral mesoderm HOX genes regulate  patterning in vertebrate limb  development Limb buds form deep to a  thick band of ectoderm Upper limb buds visible @  day 26-27 & lower limbs a  couple days later
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Limb Buds Limb buds consist of a mass of mesenchyme covered  by ectoderm Mensenchyme is derived from the somatic layer of lateral  mesoderm Limb buds elongate by proliferation of the mesenchyme Position of the limbs determined 1 st  by the  mesodermal cells Position of upper limb appears to be disproportionately low  on embryo’s trunk  because of early cranial development
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