Inflammatory Response Study Guide

Inflammatory Response Study Guide - Inflammatory Response...

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Inflammatory Response lines of defense (3 lines) Nonspecific (1 st ): skin, mucous membranes, secretions such as saliva or tears Nonspecific (2 nd ): phagocytosis, inflammation o Phagocytosis: neutrophils/macrophages eat and destroy bacteria, cell debris or foreign materials o Inflammation: sequence of events that limit effects of injury. Interferons: nonspecific agents that protect uninfected cells against viruses Specific (3 rd ): (immune system) production of specific antibodies and sensitized lymphocytes following exposure to specific substances local signs of inflammation Redness- (rubor, erythema) caused by increased blood flow into damaged area Heat-caused by increased blood flow to damaged area Swelling- (edema) caused by shift of protein and fluid into interstitial space Pain-caused by increased pressure of fluid on nerves and by chemical mediators (bradykinins) Loss of function- may develop if cells lack nutrients or if swelling interferes mechanically w/ function systemic signs of inflammation Mild fever- (pyrexia) o Fever results from release of pyrogens by WBC or macrophages o Pyrogens cause body temp control system in hypothalamus to be reset to higher level o High fever may be beneficial because it can stop growth and reproduction of pathogenic microorganisms Malaise- (feeling ill) Fatigue Headache anorexia Cardinal signs of inflammation and causes e.g.
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  • Fall '16
  • WBC, anti-inflammatory effect, tissue. Scar tissue, identical functioning tissue, minimal tissue damage

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